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Vaccination against the feline leukaemia virus: outcome and response categories and long-term follow-up


Hofmann-Lehmann, R; Cattori, V; Tandon, R; Boretti, F S; Meli, M L; Riond, B; Pepin, A C; Willi, B; Ossent, P; Lutz, H (2007). Vaccination against the feline leukaemia virus: outcome and response categories and long-term follow-up. Vaccine, 25(30):5531-5539.

Abstract

Feline leukaemia virus (FeLV) is a pathogen inducing fatal disease in cats worldwide. By applying sensitive molecular assays, efficacious commonly used FeLV vaccines that protect cats from antigenaemia were found not to prevent proviral integration and minimal viral replication after challenge. Nonetheless, vaccines protected cats from FeLV-associated disease and prolonged life expectancy. The spectrum of host response categories was refined by investigating plasma viral RNA loads. All cats initially fought similar virus loads, although subsequently loads were associated with infection outcomes. Persistence of plasma viral RNA was moderately associated with reactivation of FeLV infection. In conclusion, sensitive molecular assays are important tools for reviewing pathogenesis of FeLV infection.

Feline leukaemia virus (FeLV) is a pathogen inducing fatal disease in cats worldwide. By applying sensitive molecular assays, efficacious commonly used FeLV vaccines that protect cats from antigenaemia were found not to prevent proviral integration and minimal viral replication after challenge. Nonetheless, vaccines protected cats from FeLV-associated disease and prolonged life expectancy. The spectrum of host response categories was refined by investigating plasma viral RNA loads. All cats initially fought similar virus loads, although subsequently loads were associated with infection outcomes. Persistence of plasma viral RNA was moderately associated with reactivation of FeLV infection. In conclusion, sensitive molecular assays are important tools for reviewing pathogenesis of FeLV infection.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2007
Deposited On:18 Aug 2008 07:21
Last Modified:05 Apr 2016 12:25
Publisher:Elsevier
ISSN:0264-410X
Publisher DOI:10.1016/j.vaccine.2006.12.022
PubMed ID:17240486
Permanent URL: http://doi.org/10.5167/uzh-3021

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