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Respiratory and cardiovascular effects of doxapram and theophylline for the treatment of asphyxia in neonatal calves


Bleul, U; Bircher, B; Jud, R; Kutter, A P N (2010). Respiratory and cardiovascular effects of doxapram and theophylline for the treatment of asphyxia in neonatal calves. Theriogenology, 73(5):612-619.

Abstract

Respiratory stimulants are widely used in asphyxic neonatal calves despite a lack of data about their effectiveness and indications of possible side effects. The effect of doxapram and theophylline on respiratory, cardiovascular, and acid-base variables was investigated in 10 healthy neonatal calves (Bos Taurus). A venous, a peripheral arterial, and a pulmonary arterial catheter were placed, and central venous, pulmonary, and systemic blood pressures and cardiac output were measured using thermodilution technique. Doxapram, but not theophylline, led to an immediate increase in respiratory rate (P </= 0.01). The arterial pCO(2) decreased to 27.1+/-4.7mm Hg within 30sec after doxapram administration and to 46.3+/-5.8mm Hg within 120min after theophylline administration (P<0.0001). The systolic pulmonary pressure increased from 70+/-8mm Hg (mean+/-SD) to 93+/-19mm Hg within 30sec after doxapram, but decreased after theophylline. The pulmonary vascular resistance also increased after doxapram and decreased after theophylline (P<0.01). Doxapram had a more pronounced and faster effect on respiratory rate and elimination of CO(2) than theophylline. Doxapram, but not theophylline, is indicated for treatment of postnatal asphyxia in calves, but there are potential cardiovascular side effects. Copyright © 2009 Elsevier Inc. All rights reserved.

Respiratory stimulants are widely used in asphyxic neonatal calves despite a lack of data about their effectiveness and indications of possible side effects. The effect of doxapram and theophylline on respiratory, cardiovascular, and acid-base variables was investigated in 10 healthy neonatal calves (Bos Taurus). A venous, a peripheral arterial, and a pulmonary arterial catheter were placed, and central venous, pulmonary, and systemic blood pressures and cardiac output were measured using thermodilution technique. Doxapram, but not theophylline, led to an immediate increase in respiratory rate (P </= 0.01). The arterial pCO(2) decreased to 27.1+/-4.7mm Hg within 30sec after doxapram administration and to 46.3+/-5.8mm Hg within 120min after theophylline administration (P<0.0001). The systolic pulmonary pressure increased from 70+/-8mm Hg (mean+/-SD) to 93+/-19mm Hg within 30sec after doxapram, but decreased after theophylline. The pulmonary vascular resistance also increased after doxapram and decreased after theophylline (P<0.01). Doxapram had a more pronounced and faster effect on respiratory rate and elimination of CO(2) than theophylline. Doxapram, but not theophylline, is indicated for treatment of postnatal asphyxia in calves, but there are potential cardiovascular side effects. Copyright © 2009 Elsevier Inc. All rights reserved.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Equine Department
05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Language:English
Date:15 March 2010
Deposited On:10 Feb 2010 14:34
Last Modified:05 Apr 2016 13:54
Publisher:Elsevier
ISSN:0093-691X
Publisher DOI:https://doi.org/10.1016/j.theriogenology.2009.10.017
PubMed ID:20022095
Permanent URL: https://doi.org/10.5167/uzh-30232

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