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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-3024

Leeming, G; Meli, M L; Cripps, P; Vaughan-Thomas, A; Lutz, H; Gaskell, R; Kipar, A (2006). Tracheal organ cultures as a useful tool to study Felid herpesvirus 1 infection in respiratory epithelium. Journal of Virological Methods, 138(1-2):191-195.

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Abstract

Felid herpesvirus 1 (FeHV-1) is an important feline pathogen of the upper respiratory tract which can be identified in clinical cases by virus isolation and PCR. Studies on the effect and mode of spread of FeHV-1 in the respiratory epithelium, however, have previously only been performed in infected cats. Feline tracheal organ cultures which were inoculated with FeHV-1 at varying multiplicity of infection (MOI) were established. A dose-dependent response was observed. Low MOIs induced multifocal infection in the otherwise viable respiratory epithelium, which allowed monitoring of viral growth over several days. Therefore, tracheal organ cultures represent a suitable model for further study of the morphological and functional effects of FeHV-1 on respiratory epithelium, mimicking the in vivo situation.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals > Clinical Laboratory
DDC:570 Life sciences; biology
630 Agriculture
Language:English
Date:2006
Deposited On:18 Aug 2008 08:14
Last Modified:27 Nov 2013 16:28
Publisher:Elsevier
ISSN:0166-0934
Publisher DOI:10.1016/j.jviromet.2006.07.010
PubMed ID:16926054

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