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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-3035

Hofmann-Lehmann, R; Tandon, R; Boretti, F S; Meli, M L; Willi, B; Cattori, V; Gomes-Keller, M A; Ossent, P; Golder, M C; Flynn, J; Lutz, H (2006). Reassessment of feline leukaemia virus (FeLV) vaccines with novel sensitive molecular assays. Vaccine, 24(8):1087-1094.

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We previously described antigen negative, provirus positive cats. Subsequently, we hypothesized that efficacious FeLV vaccines cannot prevent minimal viral replication. Thus, we vaccinated cats with either a canarypox-vectored live or a killed virus vaccine and analyzed the challenge outcome with quantitative PCR and a newly established real-time RT-PCR. When judged by conventional parameters (antigenaemia, virus isolation), most of the vaccinated cats were, as expected, protected from persistent viraemia. However, all cats were found to be plasma viral RNA positive. The loads were significantly associated with the infection outcome. Thus, commonly used FeLV vaccines understood to be successful model antiretroviral vaccines protecting against FeLV-related diseases do not confer sterilizing immunity.


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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
Deposited On:19 Aug 2008 08:58
Last Modified:05 Apr 2016 12:25
Publisher DOI:10.1016/j.vaccine.2005.09.010
PubMed ID:16198454

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