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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-3035

Hofmann-Lehmann, R; Tandon, R; Boretti, F S; Meli, M L; Willi, B; Cattori, V; Gomes-Keller, M A; Ossent, P; Golder, M C; Flynn, J; Lutz, H (2006). Reassessment of feline leukaemia virus (FeLV) vaccines with novel sensitive molecular assays. Vaccine, 24(8):1087-1094.

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Abstract

We previously described antigen negative, provirus positive cats. Subsequently, we hypothesized that efficacious FeLV vaccines cannot prevent minimal viral replication. Thus, we vaccinated cats with either a canarypox-vectored live or a killed virus vaccine and analyzed the challenge outcome with quantitative PCR and a newly established real-time RT-PCR. When judged by conventional parameters (antigenaemia, virus isolation), most of the vaccinated cats were, as expected, protected from persistent viraemia. However, all cats were found to be plasma viral RNA positive. The loads were significantly associated with the infection outcome. Thus, commonly used FeLV vaccines understood to be successful model antiretroviral vaccines protecting against FeLV-related diseases do not confer sterilizing immunity.

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals > Clinical Laboratory
05 Vetsuisse Faculty > Institute of Veterinary Pathology
DDC:570 Life sciences; biology
630 Agriculture
Language:English
Date:2006
Deposited On:19 Aug 2008 08:58
Last Modified:28 Nov 2013 01:02
Publisher:Elsevier
ISSN:0264-410X
Publisher DOI:10.1016/j.vaccine.2005.09.010
PubMed ID:16198454
Citations:Web of Science®. Times Cited: 33
Google Scholar™
Scopus®. Citation Count: 33

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