Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Bauer, M; Karch, R; Neumann, F; Wagner, C C; Kletter, K; Müller, M; Löscher, W; Zeitlinger, M; Langer, O (2010). Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism, 30(3):510-515.

Full text not available from this repository.

View at publisher


We attempted to assess regional differences in cerebral P-glycoprotein (P-gp) function by performing paired positron emission tomography (PET) scans with the P-gp substrate (R)-[(11)C]verapamil in five healthy subjects before and after i.v. infusion of tariquidar (2 mg/kg). Comparison of tariquidar-induced changes in distribution volumes (DVs) in 42 brain regions of interest (ROIs) failed to detect significant differences among brain ROIs. Statistical parametric mapping analysis of parametric DV images visualized symmetrical bilateral clusters with moderately higher DV increases in response to tariquidar administration in cerebellum, parahippocampal gyrus, olfactory gyrus, and middle temporal lobe and cortex, which might reflect moderately decreased P-gp function and expression.


19 citations in Web of Science®
18 citations in Scopus®
Google Scholar™


Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
Dewey Decimal Classification:610 Medicine & health
Deposited On:15 Feb 2010 12:33
Last Modified:05 Apr 2016 13:54
Publisher:Nature Publishing Group
Publisher DOI:10.1038/jcbfm.2009.265
PubMed ID:20010957

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page