Bauer, M; Karch, R; Neumann, F; Wagner, C C; Kletter, K; Müller, M; Löscher, W; Zeitlinger, M; Langer, O (2010). Assessment of regional differences in tariquidar-induced P-glycoprotein modulation at the human blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism, 30(3):510-515.
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We attempted to assess regional differences in cerebral P-glycoprotein (P-gp) function by performing paired positron emission tomography (PET) scans with the P-gp substrate (R)-[(11)C]verapamil in five healthy subjects before and after i.v. infusion of tariquidar (2 mg/kg). Comparison of tariquidar-induced changes in distribution volumes (DVs) in 42 brain regions of interest (ROIs) failed to detect significant differences among brain ROIs. Statistical parametric mapping analysis of parametric DV images visualized symmetrical bilateral clusters with moderately higher DV increases in response to tariquidar administration in cerebellum, parahippocampal gyrus, olfactory gyrus, and middle temporal lobe and cortex, which might reflect moderately decreased P-gp function and expression.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine|
|DDC:||610 Medicine & health|
|Deposited On:||15 Feb 2010 12:33|
|Last Modified:||27 Nov 2013 21:22|
|Publisher:||Nature Publishing Group|
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