Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-30398
Altintas, M A; Meyer-Marcotty, M; Altintas, A A; Guggenheim, M; Gohritz, A; Aust, M C; Vogt, P M (2009). In vivo reflectance-mode confocal microscopy provides insights in human skin microcirculation and histomorphology. Computerized Medical Imaging and Graphics, 33(7):532-536.
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PURPOSE: Various approaches are used to study microcirculation, however, no modality evaluates microcirculation and histomorphology on cellular levels. We hypothesized that reflectance-mode confocal microscopy (RCM) enables simultaneous evaluation in vivo of both microcirculation and histomorphology. PRINCIPALS: The forearm of 20 volunteers was exposed to either local heat stress (HS-group), or to local cold stress (CS-group). RCM was performed prior and after temperature stress to evaluate quantitative blood-cell flow, capillary loop diameter, granular cell size, and basal layer thickness. RESULTS: In the HS-group, we observed significant increase in capillary loop diameter and increased blood-cell flow after heat stress. In the CS-group, significant decreases of capillary loop diameter and in blood-cell flow were determined following cold stress. Granular cell size and basal layer thickness differed insignificantly prior and after local temperature stress. CONCLUSIONS: RCM provides real-time and in vivo high resolution imaging of temperature-dependent changes in the human skin microcirculation and histomorphology on cellular levels.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Reconstructive Surgery|
04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
|DDC:||610 Medicine & health|
|Deposited On:||14 Feb 2010 14:37|
|Last Modified:||27 Nov 2013 21:40|
|Citations:||Web of Science®. Times Cited: 5|
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