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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-3040

Kipar, A; Baptiste, K; Meli, M L; Barth, A; Knietsch, M; Reinacher, M; Lutz, H (2005). Age-related dynamics of constitutive cytokine transcription levels of feline monocytes. Experimental Gerontology, 40(3):243-248.

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Monocytes/macrophages are central mediators of inflammation and immunity and therefore of major interest in the study of immunosenescence. In healthy adult cats, monocytes have been shown to constitutively transcribe pro- and anti-inflammatory cytokines. However, in order to characterize the effect of age, feline monocyte functions were examined for changes in cytokine transcription levels in early stages of immunosenescence. For this purpose, isolated, short-term cultured monocytes from barrier-maintained adult cats of different ages (15 mo to 10 yr) were examined for transcription of IL-1 beta, IL-6, IL-10, IL-12 p40 and TNF-alpha by real-time PCR. Transcription levels of cytokines varied and were generally highest for IL-1 beta. For IL-1 beta, IL-6 and IL-12 p40, both young and old cats exhibited highest levels. The age association was significant. TNF-alpha appeared to be transcribed at similar levels over the examination period, whereas IL-10 tended to decline with age but without any statistical significant differences. The observed age association of the constitutive transcription of some cytokines indicates a drop in monocyte activities from youth to middle age, which is then followed by a (progressive) increase with increasing age. This provides evidence that monocytes are in part responsible for the pro-inflammatory status observed with ageing.

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals > Clinical Laboratory
DDC:570 Life sciences; biology
630 Agriculture
Deposited On:19 Aug 2008 09:12
Last Modified:27 Nov 2013 19:22
Publisher DOI:10.1016/j.exger.2004.12.007
PubMed ID:15763402
Citations:Web of Science®. Times Cited: 4
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Scopus®. Citation Count: 5

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