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Coronary artery disease in patients with cardiac tumors: preoperative assessment by computed tomography coronary angiography


Scheffel, H; Stolzmann, P; Plass, A; Leschka, S; Grünenfelder, J; Falk, V; Marincek, B; Alkadhi, H (2010). Coronary artery disease in patients with cardiac tumors: preoperative assessment by computed tomography coronary angiography. Interactive Cardiovascular and Thoracic Surgery, 10(4):513-518.

Abstract

We studied the diagnostic accuracy of computed tomography coronary angiography (CTCA) for the diagnosis of significant coronary artery disease (CAD) compared to conventional coronary angiography (CCA) in patients with primary cardiac tumors. Thirty-eight consecutive patients with primary cardiac tumors (27 females, 11 males; mean age 56+/-6 years, range 32-86 years) underwent dual-source CTCA and CCA. Significant stenosis was defined as diameter reduction >50%. CCA served as the standard of reference. The prevalence of significant CAD in the study population was 8% (3/38 patients). Five of 544 segments (0.9%) in 1/38 patients (2.6%) was considered of non-diagnostic image quality on CTCA because of motion artifacts. In a segment-based analysis taking not-evaluative segments as false-positive, sensitivity, specificity, positive and negative predictive value of CT was 100%, 99%, 70%, and 100%, respectively. Preoperative CCA could have been avoided in 95% (36/38) of the patients and CCA would have confirmed the CTCA diagnosis in 5% (2/38) of the patients. Our results indicate that CTCA provides a high diagnostic performance for diagnosing significant CAD in patients with primary cardiac tumors. CTCA may thus be used as a filter test prior to surgery. Keywords: Primary cardiac tumors; Coronary artery disease; Computed tomography; Conventional coronary angiography.

We studied the diagnostic accuracy of computed tomography coronary angiography (CTCA) for the diagnosis of significant coronary artery disease (CAD) compared to conventional coronary angiography (CCA) in patients with primary cardiac tumors. Thirty-eight consecutive patients with primary cardiac tumors (27 females, 11 males; mean age 56+/-6 years, range 32-86 years) underwent dual-source CTCA and CCA. Significant stenosis was defined as diameter reduction >50%. CCA served as the standard of reference. The prevalence of significant CAD in the study population was 8% (3/38 patients). Five of 544 segments (0.9%) in 1/38 patients (2.6%) was considered of non-diagnostic image quality on CTCA because of motion artifacts. In a segment-based analysis taking not-evaluative segments as false-positive, sensitivity, specificity, positive and negative predictive value of CT was 100%, 99%, 70%, and 100%, respectively. Preoperative CCA could have been avoided in 95% (36/38) of the patients and CCA would have confirmed the CTCA diagnosis in 5% (2/38) of the patients. Our results indicate that CTCA provides a high diagnostic performance for diagnosing significant CAD in patients with primary cardiac tumors. CTCA may thus be used as a filter test prior to surgery. Keywords: Primary cardiac tumors; Coronary artery disease; Computed tomography; Conventional coronary angiography.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiovascular Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:21 Mar 2010 10:59
Last Modified:05 Apr 2016 13:54
Publisher:European Association of Cardio-Thoracic Surgery
ISSN:1569-9285
Publisher DOI:https://doi.org/10.1510/icvts.2009.227439
PubMed ID:20118120
Permanent URL: https://doi.org/10.5167/uzh-30439

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