Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-30486
Donath, M Y; Böni-Schnetzler, M; Ellingsgaard, H; Halban, P A; Ehses, J A (2010). Cytokine production by islets in health and diabetes: cellular origin, regulation and function. Trends in Endocrinology and Metabolism, 21(5):261-267.
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Islets produce a variety of cytokines and chemokines in response to physiologic and pathologic stimulation by nutrients. The cellular source of these inflammatory mediators includes alpha-, beta-, endothelial-, ductal- and recruited immune cells. Islet-derived cytokines promote alpha- and beta-cell adaptation and repair in the short term. Eventually, chronic metabolic stress can induce a deleterious autoinflammatory process in islets leading to insulin secretion failure and type 2 diabetes. Understanding the specific role of islet derived cytokines and chemokines has opened the door to targeted clinical interventions aimed at remodeling islet inflammation from destruction to adaptation. In this article, we review the islet cellular origin of various cytokines and chemokines and describe their regulation and respective roles in physiology and diabetes.
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology|
04 Faculty of Medicine > Center for Integrative Human Physiology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||15 Mar 2010 11:31|
|Last Modified:||08 Jan 2014 15:55|
|Citations:||Web of Science®. Times Cited: 45|
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