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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-3070

Hernando, N; Wagner, C A; Biber, J; Murer, H (2007). Kidney kinase network regulates renal ion cotransport. Journal of Clinical Investigation, 117(11):3179-3182.

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Protein kinases catalyze the phosphorylation of serine/threonine or tyrosine residues, which may directly alter a protein's functional properties. Kinases can also regulate protein functions indirectly, for example, by controlling the composition and/or subcellular localization of members of multiprotein complexes that associate with the regulated protein. In this issue of the JCI, two separate studies by Weinman et al. and Yang et al. examine the second of these two modes of kinase-mediated regulation and demonstrate the effects of kinases on two Na(+)-driven renal cotransporters (see the related articles beginning on pages 3403 and 3412). Their results reveal important implications for phosphate and salt homeostasis, respectively.


1 citation in Web of Science®
2 citations in Scopus®
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39 downloads since deposited on 27 Mar 2009
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
Deposited On:27 Mar 2009 13:43
Last Modified:05 Apr 2016 12:25
Publisher:American Society for Clinical Investigation
Publisher DOI:10.1172/JCI33859
PubMed ID:17975663

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