Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-30707
Joller, D; Jorgensen, C B; Bertschinger, H U; Python, P; Edfors, I; Cirera, S; Archibald, A L; Bürgi, E; Karlskov-Mortensen, P; Andersson, L; Fredholm, M; Vögeli, P (2009). Refined localization of the Escherichia coliF4ab/F4ac receptor locus on pig chromosome 13. Animal Genetics, 40(5):749-752.
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Diarrhoea in newborn and weaned pigs caused by enterotoxigenic Escherichia coli (ETEC)
expressing F4 fimbriae leads to considerable losses in pig production. In this study, we
refined the mapping of the receptor locus for ETEC F4ab/F4ac adhesion (F4bcR) by joint
analysis of Nordic and Swiss data. A total of 236 pigs from a Nordic experimental herd, 331
pigs from a Swiss experimental herd and 143 pigs from the Swiss performing station were
used for linkage analysis. Genotyping data of six known microsatellite markers, two newly
developed markers (MUC4gt and HSA125gt) and an intronic SNP in MUC4 (MUC4-8227)
were used to create the linkage map. The region for F4bcR was refined to the interval
SW207–S0075 on pig chromosome 13. The most probable position of F4bcR was in the
SW207–MUC4 region. The order of six markers was supported by physical mapping on the
BAC fingerprint contig from the Wellcome Trust Sanger Institute. Thus, the region for
F4bcR could be reduced from 26 to 14 Mb.
Keywords chromosome 13, enterotoxigenic Escherichia coli, Escherichia coli, F4ab/F4ac
receptor, linkage mapping, pig.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals > Division of Swine Medicine|
|DDC:||570 Life sciences; biology|
|Deposited On:||15 Feb 2010 16:25|
|Last Modified:||23 Nov 2012 13:34|
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