Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-30712
Jacob, F; Goldstein, D R; Fink, D; Heinzelmann-Schwarz, V (2009). Proteogenomic studies in epithelial ovarian cancer: established knowledge and future needs. Biomarkers in Medicine, 3(6):743-756.
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There has been a concerted effort over the last decade to improve our understanding of the complex biology of ovarian cancer. A linear growth in published proteogenomic studies has addressed a variety of questions regarding its molecular pathogenesis. A number of genes have been identified by transcriptomic approaches, some of which are being investigated as putative tumor markers (HE4, OPN, Ep-CAM and Mesothelin), whilst others are potential targets for molecular therapeutic approaches (VEGF, IO4, EGFR, MUC1, CLDN4 and SLPI). Proteogenomics has the potential to further change our current characterization and treatment of ovarian cancer. Additional advances will depend on integrated study designs, interdisciplinary collaborations, use of robust high-throughput platforms, as well as uniform guidelines for bioinformatic analyses.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Gynecology|
|DDC:||610 Medicine & health|
|Deposited On:||18 Mar 2010 09:26|
|Last Modified:||07 Jan 2014 07:59|
|Free access at:||Official URL. An embargo period may apply.|
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