Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-30806

Rizzo, M; Kotur-Stevuljevic, J; Berneis, K; Spinas, G; Rini, G B; Jelic-Ivanovic, Z; Spasojevic-Kalimanovska, V; Vekic, J (2009). Atherogenic dyslipidemia and oxidative stress: a new look. Translational Research, 153(5):217-223.

[img] PDF - Registered users only
188kB

View at publisher

Abstract

Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk.

Citations

35 citations in Web of Science®
40 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

1 download since deposited on 17 Mar 2010
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
DDC:610 Medicine & health
Language:English
Date:2009
Deposited On:17 Mar 2010 10:03
Last Modified:01 Dec 2013 07:21
Publisher:Elsevier
ISSN:1878-1810
Publisher DOI:10.1016/j.trsl.2009.01.008
PubMed ID:19375682

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page