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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-30806

Rizzo, M; Kotur-Stevuljevic, J; Berneis, K; Spinas, G; Rini, G B; Jelic-Ivanovic, Z; Spasojevic-Kalimanovska, V; Vekic, J (2009). Atherogenic dyslipidemia and oxidative stress: a new look. Translational Research, 153(5):217-223.

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Abstract

Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
DDC:610 Medicine & health
Language:English
Date:2009
Deposited On:17 Mar 2010 11:03
Last Modified:01 Dec 2013 08:21
Publisher:Elsevier
ISSN:1878-1810
Publisher DOI:10.1016/j.trsl.2009.01.008
PubMed ID:19375682
Citations:Web of Science®. Times Cited: 30
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