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Macrogeographic population structure in a parasitic nematode with avian hosts


Webster, L M I; Johnson, P C D; Adam, A; Mable, B K; Keller, L F (2007). Macrogeographic population structure in a parasitic nematode with avian hosts. Veterinary Parasitology, 144(1-2):93-103.

Abstract

Much remains to be discovered about the population genetic structure of parasites, despite the importance of such knowledge to understanding the processes involved in the spread of drug resistance through populations. Here we present a study of population genetic diversity in Trichostrongylus tenuis, an avian parasitic nematode infecting both poultry and game birds, where anthelmintic use is common. We examined diversity of nicotinamide dehydrogenase subunit 4 (nad4) mtDNA sequences within and between seven locations: five in the UK (red grouse hosts), one in Iceland (domestic goose) and one in Norway (willow grouse).Within-UK comparisons showed high nucleotide diversity (p = 0.015, n = 23) but no structure between locations (FST = 0.022, P = 0.27), with over 97% of variation distributed within-hosts. The highest diversity was found in Iceland (p = 0.043, n = 4), and the lowest in Norway (p = 0.003, n = 4). Differentiation between countries was considerable (FCT = 0.44, P < 0.05), in spite of the potential mixing effects of gene flow via migrating wild hosts and the poultry trade. However, significant pairwise FST values were found only between Norway and the other locations. Phylogenetic analysis provided statistical support for a separate clade for Norwegian samples only, with unresolved diversity leading to a star-shaped relationship between Icelandic and UK haplotypes. These results suggest that Norwegian T. tenuis are isolated, but that there is some connectivity between UK and Icelandic populations. Although anthelmintic resistance has not yet been reported for T. tenuis, the population structure is such that emerging resistance has the potential to spread by gene flow over a large geographic scale.

Much remains to be discovered about the population genetic structure of parasites, despite the importance of such knowledge to understanding the processes involved in the spread of drug resistance through populations. Here we present a study of population genetic diversity in Trichostrongylus tenuis, an avian parasitic nematode infecting both poultry and game birds, where anthelmintic use is common. We examined diversity of nicotinamide dehydrogenase subunit 4 (nad4) mtDNA sequences within and between seven locations: five in the UK (red grouse hosts), one in Iceland (domestic goose) and one in Norway (willow grouse).Within-UK comparisons showed high nucleotide diversity (p = 0.015, n = 23) but no structure between locations (FST = 0.022, P = 0.27), with over 97% of variation distributed within-hosts. The highest diversity was found in Iceland (p = 0.043, n = 4), and the lowest in Norway (p = 0.003, n = 4). Differentiation between countries was considerable (FCT = 0.44, P < 0.05), in spite of the potential mixing effects of gene flow via migrating wild hosts and the poultry trade. However, significant pairwise FST values were found only between Norway and the other locations. Phylogenetic analysis provided statistical support for a separate clade for Norwegian samples only, with unresolved diversity leading to a star-shaped relationship between Icelandic and UK haplotypes. These results suggest that Norwegian T. tenuis are isolated, but that there is some connectivity between UK and Icelandic populations. Although anthelmintic resistance has not yet been reported for T. tenuis, the population structure is such that emerging resistance has the potential to spread by gene flow over a large geographic scale.

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12 citations in Web of Science®
14 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Evolutionary Biology and Environmental Studies
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:2007
Deposited On:27 Mar 2009 08:31
Last Modified:05 Apr 2016 12:25
Publisher:Elsevier
ISSN:0304-4017
Publisher DOI:10.1016/j.vetpar.2006.09.027
Permanent URL: http://doi.org/10.5167/uzh-3082

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