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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-3099

Ross-Gillespie, A; O'Riain, M J; Keller, L F (2007). Viral epizootic reveals inbreeding depression in a habitually inbreeding mammal. Evolution, 61(9):2268-2273.

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Abstract

Inbreeding is typically detrimental to fitness. However, some animal populations are reported to inbreed without incurring inbreeding depression, ostensibly due to past “purging” of deleterious alleles. Challenging this is the position that purging can, at best, only adapt a population to a particular environment; novel selective regimes will always uncover additional inbreeding load. We consider this in a prominent test case: the eusocial naked mole-rat (Heterocephalus glaber), one of the most inbred of all free-living mammals. We investigated factors affecting mortality in a population of naked mole-rats struck by a spontaneous, lethal coronavirus outbreak. In a multivariate model, inbreeding coefficient strongly predicted mortality, with closely inbred mole-rats (F ≥0.25) over 300% more likely to die than their outbred counterparts. We demonstrate that, contrary to common assertions, strong inbreeding depression is evident in this species. Our results suggest that loss of genetic diversity through inbreeding may render populations vulnerable to local extinction from emerging infectious diseases even when other inbreeding depression symptoms are absent.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Evolutionary Biology and Environmental Studies
DDC:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:September 2007
Deposited On:27 Mar 2009 09:35
Last Modified:02 Dec 2013 17:38
Publisher:Wiley-Blackwell
ISSN:0014-3820
Publisher DOI:10.1111/j.1558-5646.2007.00177.x
Citations:Web of Science®. Times Cited: 25
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