Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-3114

Feder-Mengus, C; Wyler, S; Hudolin, T; Ruszat, R; Bubendorf, L; Chiarugi, A; Pittelli, M; Weber, W; Bachmann, A; Gasser, T C; Sulser, T; Heberer, M; Spagnoli, G C; Provenzano, M (2008). High expression of indoleamine 2,3-dioxygenase gene in prostate cancer. European Journal of Cancer, 44(15):2266-2275.

Accepted Version
View at publisher
[img] PDF - Registered users only


Arginase 2, inducible- and endothelial-nitric-oxide synthase (iNOS and eNOS), indoleamine 2,3-dioxygenase (IDO) and TGF-beta, might impair immune functions in prostate cancer (PCA) patients. However, their expression was not comparatively analysed in PCA and benign prostatic hyperplasia (BPH). We evaluated the expression of these genes in PCA and BPH tissues. Seventy-six patients (42 BPH, 34 PCA) were enrolled. Arginase 2, eNOS and iNOS gene expression was similar in BPH and PCA tissues. TGF-beta1 gene expression was higher in BPH than in PCA tissues (p=0.035). IDO gene expression was more frequently detectable (p=0.00007) and quantitatively higher (p=0.00001) in PCA tissues than in BPH. IDO protein, expressed in endothelial cells from both BPH and PCA, was detectable in tumour cells in PCA showing evidence of high specific gene expression. In these patients, IDO gene expression correlated with kynurenine/tryptophan ratio in sera. Thus high expression of IDO gene is specifically detectable in PCA.


27 citations in Web of Science®
33 citations in Scopus®
Google Scholar™



292 downloads since deposited on 11 Nov 2008
86 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Urological Clinic
04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
Dewey Decimal Classification:610 Medicine & health
Date:October 2008
Deposited On:11 Nov 2008 12:48
Last Modified:05 Apr 2016 12:25
Publisher DOI:10.1016/j.ejca.2008.05.023
PubMed ID:18619832

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page