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The role of exercise and PGC1α in inflammation and chronic disease


Handschin, C; Spiegelman, B M (2008). The role of exercise and PGC1α in inflammation and chronic disease. Nature, 454(7203):463-469.

Abstract

Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1α has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.

Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1α has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:24 July 2008
Deposited On:03 Sep 2008 11:17
Last Modified:05 Apr 2016 12:26
Publisher:Nature Publishing Group
ISSN:0028-0836
Publisher DOI:10.1038/nature07206
PubMed ID:18650917
Permanent URL: http://doi.org/10.5167/uzh-3124

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