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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-31356

Gassmann, M; Soliz, J (2009). Erythropoietin modulates the neural control of hypoxic ventilation. Cellular and Molecular Life Sciences, 66(22):3575-3582.

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Abstract

Numerous factors involved in general homeostasis are able to modulate ventilation. Classically, this comprises several kind of molecules, including neurotransmitters and steroids that are necessary for fine tuning ventilation under different conditions such as sleep, exercise, and acclimatization to high altitude. Recently, however, we have found that erythropoietin (Epo), the main regulator of red blood cell production, influences both central (brainstem) and peripheral (carotid bodies) respiratory centers when the organism is exposed to hypoxic conditions. Here, we summarize the effect of Epo on the respiratory control in mammals and highlight the potential implication of Epo in the ventilatory acclimatization to high altitude, as well as in the several respiratory sickness and syndromes occurring at low and high altitude.

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
04 Faculty of Medicine > Center for Integrative Human Physiology
DDC:570 Life sciences; biology
610 Medicine & health
Date:November 2009
Deposited On:18 Feb 2010 16:26
Last Modified:27 Nov 2013 23:59
Publisher:Springer
ISSN:1420-682X
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s00018-009-0142-z
PubMed ID:19756385
Citations:Web of Science®. Times Cited: 3
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