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A mycobacterial smc null mutant is proficient in DNA repair and long-term survival


Güthlein, C; Wanner, R M; Sander, P; Böttger, E C; Springer, B (2008). A mycobacterial smc null mutant is proficient in DNA repair and long-term survival. Journal of Bacteriology, 190(1):452-456.

Abstract

SMC (structural maintenance of chromosomes) proteins play fundamental roles in various aspects of chromosome organization and dynamics, including repair of DNA damage. Mutant strains of Mycobacterium smegmatis and Mycobacterium tuberculosis defective in SMC were constructed. Surprisingly, inactivation of smc did not result in recognizable phenotypes in hallmark assays characteristic for the function of these genes. This is in contrast to data for smc null mutants in other species.

SMC (structural maintenance of chromosomes) proteins play fundamental roles in various aspects of chromosome organization and dynamics, including repair of DNA damage. Mutant strains of Mycobacterium smegmatis and Mycobacterium tuberculosis defective in SMC were constructed. Surprisingly, inactivation of smc did not result in recognizable phenotypes in hallmark assays characteristic for the function of these genes. This is in contrast to data for smc null mutants in other species.

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12 citations in Web of Science®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Microbiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:January 2008
Deposited On:09 Sep 2008 11:32
Last Modified:05 Apr 2016 12:26
Publisher:American Society for Microbiology
ISSN:0021-9193
Additional Information:Copyright: American Society for Microbiology
Publisher DOI:10.1128/JB.01315-07
PubMed ID:17981972
Permanent URL: http://doi.org/10.5167/uzh-3144

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