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Characterization of a mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264


Dittrich, D; Keller, C; Ehlers, S; Schultz, J E; Sander, P (2006). Characterization of a mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264. International Journal of Medical Microbiology, 296(8):563-566.

Abstract

Mycobacterium tuberculosis open reading frame Rv1264 encodes an adenylate cyclase that exhibits its highest enzymatic activity at an acidic pH of 6.0. This is the pH M. tuberculosis encounters in the phagosome. Consequently Rv1264 has been suggested to sense the phagosomal milieu resulting in adaption of M. tuberculosis to its intracellular niche. A targeted knock-out mutant deficient in Rv1264, however, exhibits wild-type virulence.

Mycobacterium tuberculosis open reading frame Rv1264 encodes an adenylate cyclase that exhibits its highest enzymatic activity at an acidic pH of 6.0. This is the pH M. tuberculosis encounters in the phagosome. Consequently Rv1264 has been suggested to sense the phagosomal milieu resulting in adaption of M. tuberculosis to its intracellular niche. A targeted knock-out mutant deficient in Rv1264, however, exhibits wild-type virulence.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Microbiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2006
Deposited On:26 Mar 2009 12:28
Last Modified:05 Apr 2016 12:26
Publisher:Elsevier
ISSN:1438-4221
Publisher DOI:10.1016/j.ijmm.2006.07.001
PubMed ID:17005450
Permanent URL: http://doi.org/10.5167/uzh-3146

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