Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-3146
Dittrich, D; Keller, C; Ehlers, S; Schultz, J E; Sander, P (2006). Characterization of a mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264. International Journal of Medical Microbiology, 296(8):563-566.
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Mycobacterium tuberculosis open reading frame Rv1264 encodes an adenylate cyclase that exhibits its highest enzymatic activity at an acidic pH of 6.0. This is the pH M. tuberculosis encounters in the phagosome. Consequently Rv1264 has been suggested to sense the phagosomal milieu resulting in adaption of M. tuberculosis to its intracellular niche. A targeted knock-out mutant deficient in Rv1264, however, exhibits wild-type virulence.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Medical Microbiology|
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||26 Mar 2009 13:28|
|Last Modified:||27 Nov 2013 19:46|
|Citations:||Web of Science®. Times cited: 10|
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