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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-31461

Goebel, A; Baranowski, A; Maurer, K; Ghiai, A; McCabe, C; Ambler, G (2010). Intravenous immunoglobulin treatment of the complex regional pain syndrome: a randomized trial. Annals of Internal Medicine, 152(3):152-158.

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Abstract

BACKGROUND: Treatment of long-standing complex regional pain syndrome (CRPS) is empirical and often of limited efficacy. Preliminary data suggest that the immune system is involved in sustaining this condition and that treatment with low-dose intravenous immunoglobulin (IVIG) may substantially reduce pain in some patients. OBJECTIVE: To evaluate the efficacy of IVIG in patients with longstanding CRPS under randomized, controlled conditions. DESIGN: A randomized, double-blind, placebo-controlled crossover trial. (National Research Registry number: N0263177713; International Standard Randomised Controlled Trial Number Registry: 63918259) SETTING: University College London Hospitals Pain Management Centre. PATIENTS: Persons who had pain intensity greater than 4 on an 11-point (0 to 10) numerical rating scale and had CRPS for 6 to 30 months that was refractory to standard treatment. INTERVENTION: IVIG, 0.5 g/kg, and normal saline in separate treatments, divided by a washout period of at least 28 days. MEASUREMENTS: The primary outcome was pain intensity 6 to 19 days after the initial treatment and the crossover treatment. RESULTS: 13 eligible participants were randomly assigned between November 2005 and May 2008; 12 completed the trial. The average pain intensity was 1.55 units lower after IVIG treatment than after saline (95% CI, 1.29 to 1.82; P < 0.001). In 3 patients, pain intensity after IVIG was less than after saline by 50% or more. No serious adverse reactions were reported. LIMITATION: The trial was small, and recruitment bias and chance variation could have influenced results and their interpretation. CONCLUSION: IVIG, 0.5 g/kg, can reduce pain in refractory CRPS. Studies are required to determine the best immunoglobulin dose, the duration of effect, and when repeated treatments are needed. PRIMARY FUNDING SOURCE: Association of Anaesthetists of Great Britain and Ireland, University College London Hospitals Charity, and CSL-Behring.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Anesthesiology
DDC:610 Medicine & health
Language:English
Date:2010
Deposited On:22 Mar 2010 16:17
Last Modified:27 Nov 2013 22:22
Publisher:American College of Physicians / HighWire Press
ISSN:0003-4819
Free access at:Official URL. An embargo period may apply.
Official URL:http://www.annals.org/site/collections/rct_pdf/0000605-201002020-00006.pdf
Related URLs:http://www.annals.org/content/152/3/152.abstract (Publisher)
PubMed ID:20124231
Citations:Web of Science®. Times Cited: 44
Google Scholar™
Scopus®. Citation Count: 46

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