Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Traupe, T; Keller, M; Fojtu, E; Bhattacharya, I; Lang, M; Ha, H R; Jochum, W; Mundy, A L; Barton, M (2007). Antioxidant activity and sex differences of acute vascular effects of amiodarone in advanced atherosclerosis. Journal of Cardiovascular Pharmacology, 50(5):578-584.

Full text not available from this repository.

View at publisher

Abstract

Sexual dimorphisms of atherosclerosis and the susceptibility to arrhythmias and antiarrhythmic treatment have been reported. This study investigated acute effects of amiodarone on endothelium-dependent relaxation in the aorta of male and female apoE0 mice with advanced atherosclerosis. Amiodarone tissue uptake was quantified by high-performance liquid chromatography, and xanthine oxidase-dependent superoxide anion formation was investigated in vitro in presence or absence of amiodarone. Incubation with amiodarone for 30 min improved endothelium-dependent relaxation, which was associated with rapid vascular accumulation of amiodarone (P < 0.001) that was sex-dependent. In males, reduced endothelium-dependent relaxation was improved by amiodarone (from 88 +/- 3% to 100 +/- 2%, P < 0.01). Spontaneous phasic contractions, which were greater in females than in males (P < 0.001), were completely abolished by amiodarone (P < 0.0001). Amiodarone also inhibited generation of superoxide anion (P < 0.0001). These data show that amiodarone rapidly accumulates in atherosclerotic vascular tissue, abolishes vascular autorhythmicity, and improves endothelium-dependent function in atherosclerotic arteries. Antioxidant and vasodilator effects following amiodarone administration may contribute to its antiarrhythmic effects.

Citations

4 citations in Web of Science®
4 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
DDC:610 Medicine & health
Language:English
Date:November 2007
Deposited On:22 Aug 2008 14:34
Last Modified:23 Nov 2012 13:21
Publisher:Lippincott Wiliams & Wilkins
ISSN:0160-2446
Publisher DOI:10.1097/FJC.0b013e31814d6674
PubMed ID:18030069

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page