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Prävention von Infektionen und Thrombosen nach Splenektomie oder bei Funktionsverlust der Milz


Engelhardt, M; Haas, P S; Theilacker, C; Eber, S W; Schmugge, M; Kern, W V; Heimpel, H (2009). Prävention von Infektionen und Thrombosen nach Splenektomie oder bei Funktionsverlust der Milz. Deutsche Medizinische Wochenschrift, 134(17):897-902.

Abstract

Overwhelming Post-Splenectomy Infection (OPSI or PSS), most frequently caused by encapsulated Gram-positive pathogens, is a complication after splenectomy. Reasons for splenectomy include trauma, or malignant and non-malignant hematologic diseases. OPSI-inducing bacteria are mainly Streptococcus pneumoniae and less frequently Haemophilus influenzae, Neisseria meningitides and Gram-negative bacilli. There exist very efficient--albeit often neglected--strategies, how to prevent infections in patients after splenectomy. These include vaccination, prophylactic antibiotics (always for 3 years during childhood and adolescence) and prompt antibiotic treatment, if an infection is suspected. Patients need to know the nature and likelihood of PSS and they should seek immediate medical attention if they become ill or febrile. Each patient should carry at all times a letter or card documenting the splenectomy. With these measures and precautions, the PSS-risk can be significantly reduced or at best be completely avoided.

Overwhelming Post-Splenectomy Infection (OPSI or PSS), most frequently caused by encapsulated Gram-positive pathogens, is a complication after splenectomy. Reasons for splenectomy include trauma, or malignant and non-malignant hematologic diseases. OPSI-inducing bacteria are mainly Streptococcus pneumoniae and less frequently Haemophilus influenzae, Neisseria meningitides and Gram-negative bacilli. There exist very efficient--albeit often neglected--strategies, how to prevent infections in patients after splenectomy. These include vaccination, prophylactic antibiotics (always for 3 years during childhood and adolescence) and prompt antibiotic treatment, if an infection is suspected. Patients need to know the nature and likelihood of PSS and they should seek immediate medical attention if they become ill or febrile. Each patient should carry at all times a letter or card documenting the splenectomy. With these measures and precautions, the PSS-risk can be significantly reduced or at best be completely avoided.

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11 citations in Scopus®
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Additional indexing

Other titles:Prevention of infections and thromboses after splenectomy or because of functional loss of the spleen
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:2009
Deposited On:22 Feb 2010 10:09
Last Modified:05 Apr 2016 13:58
Publisher:Thieme
ISSN:0012-0472
Additional Information:Copyright: Georg Thieme Verlag
Publisher DOI:10.1055/s-0029-1220231
PubMed ID:19337961
Permanent URL: http://doi.org/10.5167/uzh-31524

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