Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-31859

Milleret, V; Simonet, M; Bittermann, A G; Neuenschwander, P; Hall, H (2009). Cyto- and hemocompatibility of a biodegradable 3D-scaffold material designed for medical applications. Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 91B(1):109-121.

[img] PDF - Registered users only
View at publisher


In this study, the polyester urethane Degrapol® (DP) was explored for medical applications. Electrospun DP-fiber fleeces were characterized with regard to fiber morphology, swelling, and interconnectivity of interfiber spaces. Moreover, DP was assayed for cell proliferation and hemocompatibility being a prerequisite to any further in vivo application. It was shown that DP-fiber fleeces produced at different humidity while spinning affects interconnectivity of interfiber spaces, such that the higher the humidity the looser the resulting fiber fleeces. When the spinning target was cooled with dry ice, the resulting DP-fibers remained less fused to each other. However, permeability for fluorescent beads was not significantly increased. Fibroblast adhesion and proliferation occurred in a comparable manner on native as well as on fibronectin or collagen I adsorbed DP-fiber fleeces. On DP-surfaces fibroblasts proliferated equally well as compared with glass or PLGA surfaces or DP-surfaces adsorbed with fibronectin or collagen I. In contrast, human umbilical vein endothelial cells proliferated only after adsorption of DP-surfaces with fibronectin or collagen I, indicating that different cell types respond differently to DP-surfaces. Furthermore, hemocompatibility of DP-surfaces was found to be similar or better to PLGA or stainless steel, both medically used materials. These experiments indicate that DP-fiber fleeces or surfaces might be useful for tissue engineering.


11 citations in Web of Science®
12 citations in Scopus®
Google Scholar™



0 downloads since deposited on 21 Feb 2010
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Microscopy and Image Analysis
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:October 2009
Deposited On:21 Feb 2010 16:09
Last Modified:05 Apr 2016 13:59
Publisher DOI:10.1002/jbm.b.31379
Other Identification Number:10.1002/jbm.b.31379

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page