Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-31902
Knowles, T P J; Waudby, C A; Devlin, G L; Cohen, S I A; Aguzzi, A; Vendruscolo, M; Terentjev, E M; Welland, M E; Dobson, C M (2009). An analytical solution to the kinetics of breakable filament assembly. Science, 326(5959):1533-1537.
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We present an analytical treatment of a set of coupled kinetic equations that governs the self-assembly of filamentous molecular structures. Application to the case of protein aggregation demonstrates that the kinetics of amyloid growth can often be dominated by secondary rather than by primary nucleation events. Our results further reveal a range of general features of the growth kinetics of fragmenting filamentous structures, including the existence of generic scaling laws that provide mechanistic information in contexts ranging from in vitro amyloid growth to the in vivo development of mammalian prion diseases.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||05 Mar 2010 15:11|
|Last Modified:||04 Dec 2013 17:17|
|Publisher:||American Association for the Advancement of Science (AAAS)|
|Citations:||Web of Science®. Times Cited: 225|
Scopus®. Citation Count: 249
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