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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-32001

Gold, C; Girardin, C C; Martin, K A C; Koch, C (2009). High-amplitude positive spikes recorded extracellularly in cat visual cortex. Journal of Neurophysiology, 102(6):3340-3351.

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We simulated the shape and amplitude of extracellular action potentials (APs or "spikes") using biophysical models based on detailed reconstructions of single neurons from the cat's visual cortex. We compared these predictions with spikes recorded from the cat's primary visual cortex under a standard protocol. The experimental data were derived from a large number of neurons throughout all layers. The majority of spikes were biphasic, with a dominant negative peak (mean amplitude, -0.11 mV), whereas a minority of APs had a dominant positive peak of +0.54-mV mean amplitude, with a maximum of +1.5 mV. The largest positive amplitude spikes were recorded in layer 5. The simulations demonstrated that a pyramidal neuron under known biophysical conditions may generate a negative peak with amplitude up to -1.5 mV, but that the amplitude of the positive peak may be at most 0.5 mV. We confirmed that spikes with large positive peaks were not produced by juxtacellular patch recordings. We conclude that there is a significant gap in our present understanding of either the spike-generation process in pyramidal neurons, the biophysics of extracellular recording, or both.


8 citations in Web of Science®
7 citations in Scopus®
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35 downloads since deposited on 28 Feb 2010
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Neuroinformatics
Dewey Decimal Classification:570 Life sciences; biology
Date:December 2009
Deposited On:28 Feb 2010 11:07
Last Modified:05 Apr 2016 13:59
Publisher:American Physiological Society
Publisher DOI:10.1152/jn.91365.2008
Related URLs:http://www.ini.uzh.ch/node/24231 (Organisation)
PubMed ID:19793873

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