Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-32041
Pang, Daniel S J; Robledo, C J; Carr, D R; Gent, T C; Vyssotski, A L; Caley, A; Zecharia, A Y; Wisden, W; Brickley, S G; Franks, N P (2009). An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106(41):17546-17551.
View at publisher
TASK channels are acid-sensitive and anesthetic-activated members of the family of two-pore-domain potassium channels. We have made the surprising discovery that the genetic ablation of TASK-3 channels eliminates a specific type of theta oscillation in the cortical electroencephalogram (EEG) resembling type II theta (4-9 Hz), which is thought to be important in processing sensory stimuli before initiating motor activity. In contrast, ablation of TASK-1 channels has no effect on theta oscillations. Despite the absence of type II theta oscillations in the TASK-3 knockout (KO) mice, the related type I theta, which has certain neuronal pathways in common and is involved in exploratory behavior, is unaffected. In addition to the absence of type II theta oscillations, the TASK-3 KO animals show marked alterations in both anesthetic sensitivity and natural sleep behavior. Their sensitivity to halothane, a potent activator of TASK channels, is greatly reduced, whereas their sensitivity to cyclopropane, which does not activate TASK-3 channels, is unchanged. The TASK-3 KO animals exhibit a slower progression from their waking to sleeping states and, during their sleeping period, their sleep episodes as well as their REM theta oscillations are more fragmented. These results imply a previously unexpected role for TASK-3 channels in the cellular mechanisms underlying these behaviors and suggest that endogenous modulators of these channels may regulate theta oscillations.
44 downloads since deposited on 06 Mar 2010
17 downloads since 12 months
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Institute of Neuroinformatics|
|Dewey Decimal Classification:||570 Life sciences; biology|
|Uncontrolled Keywords:||EEG, knockout, REM, theta, wavelet|
|Deposited On:||06 Mar 2010 16:15|
|Last Modified:||05 Apr 2016 14:00|
|Publisher:||National Academy of Sciences|
|Related URLs:||http://www.ini.uzh.ch/node/24433 (Organisation)|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page