Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-32041
Pang, Daniel S J; Robledo, C J; Carr, D R; Gent, T C; Vyssotski, A L; Caley, A; Zecharia, A Y; Wisden, W; Brickley, S G; Franks, N P (2009). An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106(41):17546-17551.
TASK channels are acid-sensitive and anesthetic-activated members of the family of two-pore-domain potassium channels. We have made the surprising discovery that the genetic ablation of TASK-3 channels eliminates a specific type of theta oscillation in the cortical electroencephalogram (EEG) resembling type II theta (4-9 Hz), which is thought to be important in processing sensory stimuli before initiating motor activity. In contrast, ablation of TASK-1 channels has no effect on theta oscillations. Despite the absence of type II theta oscillations in the TASK-3 knockout (KO) mice, the related type I theta, which has certain neuronal pathways in common and is involved in exploratory behavior, is unaffected. In addition to the absence of type II theta oscillations, the TASK-3 KO animals show marked alterations in both anesthetic sensitivity and natural sleep behavior. Their sensitivity to halothane, a potent activator of TASK channels, is greatly reduced, whereas their sensitivity to cyclopropane, which does not activate TASK-3 channels, is unchanged. The TASK-3 KO animals exhibit a slower progression from their waking to sleeping states and, during their sleeping period, their sleep episodes as well as their REM theta oscillations are more fragmented. These results imply a previously unexpected role for TASK-3 channels in the cellular mechanisms underlying these behaviors and suggest that endogenous modulators of these channels may regulate theta oscillations.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Institute of Neuroinformatics|
|DDC:||570 Life sciences; biology|
|Uncontrolled Keywords:||EEG, knockout, REM, theta, wavelet|
|Deposited On:||06 Mar 2010 17:15|
|Last Modified:||27 Nov 2013 23:41|
|Publisher:||National Academy of Sciences|
|Related URLs:||http://www.ini.uzh.ch/node/24433 (Organisation)|
|Citations:||Web of Science®. Times Cited: 22|
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