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Exploring metal ion coordination to nucleic acids by NMR


Johannsen, S; Korth, M; Schnabl, J; Sigel, Roland K O (2009). Exploring metal ion coordination to nucleic acids by NMR. CHIMIA International Journal for Chemistry, 63(3):146-152.

Abstract

Metal ions play a crucial role in charge compensation, folding and stabilization of tertiary structures of large nucleic acids. In addition, they may be directly involved in the catalytic mechanism of ribozymes. Most metal ions applied in the context of nucleic acids in vivo and in vitro bind in a kinetically labile fashion. Hence, the detection of metal ion binding sites, not to mention the elucidation of the specific coordination sphere, still poses largely unresolved problems. Here we describe the different strategies applied and the progress made over the last years to characterize metal ion coordination to large nucleic acids by NMR.

Metal ions play a crucial role in charge compensation, folding and stabilization of tertiary structures of large nucleic acids. In addition, they may be directly involved in the catalytic mechanism of ribozymes. Most metal ions applied in the context of nucleic acids in vivo and in vitro bind in a kinetically labile fashion. Hence, the detection of metal ion binding sites, not to mention the elucidation of the specific coordination sphere, still poses largely unresolved problems. Here we describe the different strategies applied and the progress made over the last years to characterize metal ion coordination to large nucleic acids by NMR.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:March 2009
Deposited On:03 Mar 2010 18:51
Last Modified:08 Nov 2016 08:01
Publisher:Swiss Chemical Society
ISSN:0009-4293
Additional Information:Copyright ©Swiss Chemical Society: CHIMIA International Journal for Chemistry, Volume 63, Number 3, March 2009 , pp. 146-152
Publisher DOI:https://doi.org/10.2533/chimia.2009.146
Permanent URL: https://doi.org/10.5167/uzh-32270

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