Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Sirena, D; Ruzsics, Z; Schaffner, Walter; Greber, U F; Hemmi, S (2005). The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3. Virology, 343(2):283-298.

Full text not available from this repository.

View at publisher

Abstract

Human adenovirus (Ad) serotype 3 causes respiratory infections. It is considered highly virulent, accounting for about 13% of all Ad isolates. We report here the complete Ad3 DNA sequence of 35,343 base pairs (GenBank accession DQ086466). Ad3 shares 96.43% nucleotide identity with Ad7, another virulent subspecies B1 serotype, and 82.56 and 62.75% identity with the less virulent species B2 Ad11 and species C Ad5, respectively. The genomic organization of Ad3 is similar to the other human Ads comprising five early transcription units, E1A, E1B, E2, E3, and E4, two delayed early units IX and IVa2, and the major late unit, in total 39 putative and 7 hypothetical open reading frames. A recombinant E1-deleted Ad3 was generated on a bacterial artificial chromosome. This prototypic virus efficiently transduced CD46-positive rodent and human cells. Our results will help in clarifying the biology and pathology of adenoviruses and enhance therapeutic applications of viral vectors in clinical settings.

Citations

29 citations in Web of Science®
30 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:20 December 2005
Deposited On:11 Feb 2008 12:14
Last Modified:27 Nov 2013 22:00
Publisher:Elsevier
ISSN:0042-6822
Publisher DOI:10.1016/j.virol.2005.08.024
PubMed ID:16169033

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page