Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-32587
Liu, X; Alexiou, M; Martin-Orozco, N; Chung, Y; Nurieva, R I; Ma, L; Tian, Q; Kollias, G; Lu, S; Graf, D; Dong, C (2009). Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction. Journal of Immunology, 182(8):4516-4520.
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T cell activation and tolerance are delicately regulated by costimulatory molecules. Although B and T lymphocyte attenuator (BTLA) has been shown as a negative regulator for T cell activation, its role in peripheral T cell tolerance induction in vivo has not been addressed. In this study, we generated a novel strain of BTLA-deficient mice and used three different models to characterize the function of BTLA in controlling T cell tolerance. In an oral tolerance model, BTLA-deficient mice were found resistant to the induction of T cell tolerance to an oral Ag. Moreover, compared with wild-type OT-II cells, BTLA(-/-) OT-II cells were less susceptible to tolerance induction by a high-dose OVA peptide administered i.v. Finally, BTLA(-/-) OT-I cells caused autoimmune diabetes in RIP-mOVA recipient mice. Our results thus demonstrate an important role for BTLA in the induction of peripheral tolerance of both CD4(+) and CD8(+) T cells in vivo.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Center for Dental Medicine > Institute of Oral Biology|
|DDC:||610 Medicine & health|
|Deposited On:||27 Feb 2010 10:09|
|Last Modified:||28 Nov 2013 01:55|
|Publisher:||American Association of Immunologists|
|Related URLs:||http://www.jimmunol.org/ (Publisher)|
|Citations:||Web of Science®. Times Cited: 21|
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