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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-32669

Bach, D R; Herdener, M; Grandjean, D; Sander, D; Seifritz, E; Strik, W K (2009). Altered lateralisation of emotional prosody processing in schizophrenia. Schizophrenia Research, 110(1-3):180-187.

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Abstract

Alterations of cerebral lateralisation in schizophrenia have been reported consistently, and a reduced left-lateralisation has been suggested for language functions. Speech contains non-verbal information, e.g. prosody, and on a behavioural level, the extraction of emotional information from prosody is often impaired in schizophrenia. A previous functional magnetic resonance imaging study suggests increased left-lateralisation in schizophrenia during prosody processing, but did not disentangle effects of speech processing as such and emotional prosody processing. Here, we used meaningless syllables spoken with neutral, angry or fearful speech melody and measured blood oxygen level-dependent (BOLD) responses in 15 in-patients with schizophrenia and 15 healthy control participants matched for age and gender. Lateralisation indices were calculated for responses to emotional versus neutral prosody, and for all types of prosody versus baseline. Compared to control participants, patients with schizophrenia showed an increased right-lateralisation of emotional and non-emotional prosody processing in the temporal and parietal cortex. This right-lateralisation was increased in patients with reduced right-handedness and decreased in patients with stronger negative symptoms, particularly affective blunting, and with longer hospitalisation. Although patients with schizophrenia performed worse in emotion identification, this deficit was not related to lateralisation indices. Enhanced right-lateralisation to prosody resembles previous findings on laterality changes in speech processing and might suggest a common underlying cause in the organization of language functions.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
DDC:610 Medicine & health
Language:English
Date:May 2009
Deposited On:09 Mar 2010 11:08
Last Modified:11 Dec 2013 14:32
Publisher:Elsevier
ISSN:0006-3223
Publisher DOI:10.1016/j.schres.2009.02.011
PubMed ID:19285381
Citations:Web of Science®. Times Cited: 19
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Scopus®. Citation Count: 18

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