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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-32858

Spingler, B; Da Pieve, C; Medina-Molner, A; Antoni, P M; Santangelo, M G (2009). Interaction of novel metal complexes with DNA: synthetic and structural aspects. CHIMIA International Journal for Chemistry, 63(3):153-156.



Metal ions bind to nucleic acids at various positions. This binding can be modulated by using metal complexes with appropriate ligands. Novel mono- and especially dinuclear metal complexes could be a powerful tool to detect rare, but still physiologically relevant, forms of DNA, e.g. the left-handed Z-DNA. In this review, our recent research activities in this area of bioinorganic chemistry are summarized. A special emphasis is laid on the synthetic challenges that arose upon the synthesis of the polyamine ligands. Further, some rather unusual approaches to elucidate the solution structure of copper bound to guanosine monophosphate with the help of pulsed EPR techniques like ENDOR and HYSCORE are described.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
DDC:540 Chemistry
Date:March 2009
Deposited On:12 Mar 2010 08:20
Last Modified:27 Nov 2013 18:50
Publisher:Swiss Chemical Society
Additional Information:Copyright ©Swiss Chemical Society: CHIMIA, Volume 63, Number 3, March 2009 , pp. 153-156
Publisher DOI:10.2533/chimia.2009.153
Citations:Web of Science®. Times Cited: 3
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Scopus®. Citation Count: 3

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