UZH-Logo

Maintenance Infos

The outcome of pars plana vitrectomy in horses with equine recurrent uveitis with regard to the presence or absence of intravitreal antibodies against various serovars of Leptospira interrogans


Tömördy, E; Hässig, M; Spiess, B M (2010). The outcome of pars plana vitrectomy in horses with equine recurrent uveitis with regard to the presence or absence of intravitreal antibodies against various serovars of Leptospira interrogans. Pferdeheilkunde, 26(2):251-254.

Abstract

Purpose: To evaluate the outcome of pars plana vitrectomy (PPV) in eyes with clinical signs of equine recurrent uveitis (ERU) testing positive
or negative for intravitreal antibodies against various serovars of Leptospira interrogans. 47 eyes of horses with ERU in which intraoperative
vitreous samples were tested by microagglutination (MAT) for various serovars of Leptospira interrogans between 2001 and 2009
were included in a retrospective study. The presence or absence of postoperative ERU was evaluated by repeated ocular examinations, as
well as by interrogation of referring veterinarians and owners. The absence of recurrent episodes of active uveitis was considered a success
irrespective of the visual performance of the operated eyes. 85% of eyes of horses with ERU had antibodies against L. interrogans in
their vitreous. The most common serovar was L. grippothyphosa. The majority of horses testing positive for antibodies against L. interrogans
(40/47; 82.5%) showed no further episodes of ERU, while 6/7 (85.7%) of horses testing negative continued to experience episodes
of ERU. This difference is statistically significant. It appears that PPV is an effective treatment for Leptospira-associated ERU but not for eyes
testing negative for antibodies against L. interrogans. Vitreal and aqueous humor samples of horses suffering from ERU should be tested
by MAT before performing a PPV.
Keywords: Equine recurrent uveitis, vitrectomy, Leptospira interrogans, antibodies, ophthalmology

Purpose: To evaluate the outcome of pars plana vitrectomy (PPV) in eyes with clinical signs of equine recurrent uveitis (ERU) testing positive
or negative for intravitreal antibodies against various serovars of Leptospira interrogans. 47 eyes of horses with ERU in which intraoperative
vitreous samples were tested by microagglutination (MAT) for various serovars of Leptospira interrogans between 2001 and 2009
were included in a retrospective study. The presence or absence of postoperative ERU was evaluated by repeated ocular examinations, as
well as by interrogation of referring veterinarians and owners. The absence of recurrent episodes of active uveitis was considered a success
irrespective of the visual performance of the operated eyes. 85% of eyes of horses with ERU had antibodies against L. interrogans in
their vitreous. The most common serovar was L. grippothyphosa. The majority of horses testing positive for antibodies against L. interrogans
(40/47; 82.5%) showed no further episodes of ERU, while 6/7 (85.7%) of horses testing negative continued to experience episodes
of ERU. This difference is statistically significant. It appears that PPV is an effective treatment for Leptospira-associated ERU but not for eyes
testing negative for antibodies against L. interrogans. Vitreal and aqueous humor samples of horses suffering from ERU should be tested
by MAT before performing a PPV.
Keywords: Equine recurrent uveitis, vitrectomy, Leptospira interrogans, antibodies, ophthalmology

Citations

10 citations in Web of Science®
11 citations in Scopus®
Google Scholar™

Downloads

151 downloads since deposited on 23 Mar 2010
44 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Equine Department
05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Language:English
Date:2010
Deposited On:23 Mar 2010 16:30
Last Modified:05 Apr 2016 14:03
Publisher:Hippiatrika Verlag GmbH
ISSN:0177-7726
Related URLs:http://www.pferdeheilkunde.de/ (Publisher)
Permanent URL: https://doi.org/10.5167/uzh-32906

Download

[img]
Preview
Filetype: PDF
Size: 1MB

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations