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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-32906

Tömördy, E; Hässig, M; Spiess, B M (2010). The outcome of pars plana vitrectomy in horses with equine recurrent uveitis with regard to the presence or absence of intravitreal antibodies against various serovars of Leptospira interrogans. Pferdeheilkunde, 26(2):251-254.



Purpose: To evaluate the outcome of pars plana vitrectomy (PPV) in eyes with clinical signs of equine recurrent uveitis (ERU) testing positive
or negative for intravitreal antibodies against various serovars of Leptospira interrogans. 47 eyes of horses with ERU in which intraoperative
vitreous samples were tested by microagglutination (MAT) for various serovars of Leptospira interrogans between 2001 and 2009
were included in a retrospective study. The presence or absence of postoperative ERU was evaluated by repeated ocular examinations, as
well as by interrogation of referring veterinarians and owners. The absence of recurrent episodes of active uveitis was considered a success
irrespective of the visual performance of the operated eyes. 85% of eyes of horses with ERU had antibodies against L. interrogans in
their vitreous. The most common serovar was L. grippothyphosa. The majority of horses testing positive for antibodies against L. interrogans
(40/47; 82.5%) showed no further episodes of ERU, while 6/7 (85.7%) of horses testing negative continued to experience episodes
of ERU. This difference is statistically significant. It appears that PPV is an effective treatment for Leptospira-associated ERU but not for eyes
testing negative for antibodies against L. interrogans. Vitreal and aqueous humor samples of horses suffering from ERU should be tested
by MAT before performing a PPV.
Keywords: Equine recurrent uveitis, vitrectomy, Leptospira interrogans, antibodies, ophthalmology

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals > Division of Herd Health
05 Vetsuisse Faculty > Veterinary Clinic > Equine Department > Division of Ophthalmology
DDC:570 Life sciences; biology
630 Agriculture
Deposited On:23 Mar 2010 16:30
Last Modified:27 Nov 2013 20:10
Publisher:Hippiatrika Verlag GmbH
Related URLs:http://www.pferdeheilkunde.de/ (Publisher)
Citations:Web of Science®. Times Cited: 5
Google Scholar™
Scopus®. Citation Count: 5

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