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Immunosuppressive therapy in lung transplantation: state of the art


Korom, S; Boehler, A; Weder, W (2009). Immunosuppressive therapy in lung transplantation: state of the art. European Journal of Cardio-Thoracic Surgery, 35(6):1045-1055.

Abstract

The coming of age of lung transplantation is accompanied by an immunosuppressive armamentarium that has been brought forward from other transplant indications. Widely employed on the basis of few small randomized studies, and mostly single-center experience or empirical expert knowledge, anti-rejection therapeutic strategies in pulmonary transplantation have hardly been rigorously evaluated in large-scale prospective international trials. This review compiles the available findings on the use of current immunosuppressants in clinical lung transplantation, accentuating high level-of-evidence study results. Reporting on recent meeting and registry data, and assembling ongoing relevant trials from international databases, this article serves as an update on the state of the art of immunosuppression in lung transplantation.

The coming of age of lung transplantation is accompanied by an immunosuppressive armamentarium that has been brought forward from other transplant indications. Widely employed on the basis of few small randomized studies, and mostly single-center experience or empirical expert knowledge, anti-rejection therapeutic strategies in pulmonary transplantation have hardly been rigorously evaluated in large-scale prospective international trials. This review compiles the available findings on the use of current immunosuppressants in clinical lung transplantation, accentuating high level-of-evidence study results. Reporting on recent meeting and registry data, and assembling ongoing relevant trials from international databases, this article serves as an update on the state of the art of immunosuppression in lung transplantation.

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21 citations in Web of Science®
24 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Thoracic Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2009
Deposited On:09 Apr 2010 08:13
Last Modified:05 Apr 2016 14:03
Publisher:Elsevier
ISSN:1010-7940
Free access at:Official URL. An embargo period may apply.
Publisher DOI:10.1016/j.ejcts.2009.02.035
Official URL:http://ejcts.ctsnetjournals.org/cgi/content/abstract/35/6/1045
PubMed ID:19349186
Permanent URL: http://doi.org/10.5167/uzh-32945

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