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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-34084

Hoffmann, F G; Storz, J F; Gorr, T A; Opazo, J C (2010). Lineage-specific patterns of functional diversification in the alpha- and beta-globin gene families of tetrapod vertebrates. Molecular Biology and Evolution, 27(5):1126-1138.

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Abstract

The alpha- and beta-globin gene families of jawed vertebrates have diversified with respect to both gene function and the developmental timing of gene expression. Phylogenetic reconstructions of globin gene family evolution have provided suggestive evidence that the developmental regulation of hemoglobin synthesis has evolved independently in multiple vertebrate lineages. For example, the embryonic beta-like globin genes of birds and placental mammals are not 1:1 orthologs. Despite the similarity in developmental expression profiles, the genes are independently derived from lineage-specific duplications of a beta-globin pro-ortholog. This suggests the possibility that other vertebrate taxa may also possess distinct repertoires of globin genes that were produced by repeated rounds of lineage-specific gene duplication and divergence. Until recently, investigations into this possibility have been hindered by the dearth of genomic sequence data from nonmammalian vertebrates. Here, we report new insights into globin gene family evolution that were provided by a phylogenetic analysis of vertebrate globins combined with a comparative genomic analysis of three key sauropsid taxa: a squamate reptile (anole lizard, Anolis carolinensis), a passeriform bird (zebra finch, Taeniopygia guttata), and a galliform bird (chicken, Gallus gallus). The main objectives of this study were 1) to characterize evolutionary changes in the size and membership composition of the alpha- and beta-globin gene families of tetrapod vertebrates and 2) to test whether functional diversification of the globin gene clusters occurred independently in different tetrapod lineages. Results of our comparative genomic analysis revealed several intriguing patterns of gene turnover in the globin gene clusters of different taxa. Lineage-specific differences in gene content were especially pronounced in the beta-globin gene family, as phylogenetic reconstructions revealed that amphibians, lepidosaurs (as represented by anole lizard), archosaurs (as represented by zebra finch and chicken), and mammals each possess a distinct independently derived repertoire of beta-like globin genes. In contrast to the ancient functional diversification of the alpha-globin gene cluster in the stem lineage of tetrapods, the physiological division of labor between early- and late-expressed genes in the beta-globin gene cluster appears to have evolved independently in several tetrapod lineages.

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
DDC:570 Life sciences; biology
Uncontrolled Keywords:Anolis • gene duplication • gene family evolution • genome evolution • hemoglobin • zebra finch
Language:English
Date:May 2010
Deposited On:15 May 2010 16:41
Last Modified:28 Nov 2013 01:50
Publisher:Oxford University Press
ISSN:0737-4038
Additional Information:This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Molecular Biology and Evolution following peer review. The definitive publisher-authenticated version Molecular Biology and Evolution 2010 27(5):1126-1138 is available online at: http://mbe.oxfordjournals.org/cgi/content/abstract/27/5/1126
Publisher DOI:10.1093/molbev/msp325
PubMed ID:20047955
Citations:Web of Science®. Times Cited: 22
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