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The partial coherence method for assessment of impaired cerebral autoregulation using nearinfrared spectroscopy: potential and limitations


De Smet, D; Jacobs, J; Ameye, L; Vanderhaegen, J; Naulaers, G; Lemmers, P; van Bel, F; Wolf, M; Van Huffel, S (2010). The partial coherence method for assessment of impaired cerebral autoregulation using nearinfrared spectroscopy: potential and limitations. In: Takahashi, E; Bruley, D F. Oxygen Transport to Tissue XXXI. USA: Springer US, 219-224.

Abstract

The most important forms of brain injury in premature infants are partly caused by disturbances in cerebral autoregulation. As changes in cerebral intravascular oxygenation (HbD), regional cerebral oxygen saturation (rSO2), and cerebral tissue oxygenation (TOI) reflect changes in cerebral blood flow (CBF), impaired autoregulation can be measured by studying the concordance between HbD/rSO2/TOI and the mean arterial blood pressure (MABP), assuming no changes in oxygen consumption, arterial oxygen saturation (SaO2), and in blood volume. We investigated the performance of the partial coherence (PCOH) method, and compared it with the coherence method (COH). The PCOH method allows the elimination of the influence of SaO2 on HbD/rSO2/TOI in a linear way. We started from long-term recordings measured in the first days of life simultaneously in 30 infants from three medical centres. We then compared the COH and PCOH results with patient clinical characteristics and outcomes, and concluded that PCOH might be a better method for assessing impaired autoregulation.

Abstract

The most important forms of brain injury in premature infants are partly caused by disturbances in cerebral autoregulation. As changes in cerebral intravascular oxygenation (HbD), regional cerebral oxygen saturation (rSO2), and cerebral tissue oxygenation (TOI) reflect changes in cerebral blood flow (CBF), impaired autoregulation can be measured by studying the concordance between HbD/rSO2/TOI and the mean arterial blood pressure (MABP), assuming no changes in oxygen consumption, arterial oxygen saturation (SaO2), and in blood volume. We investigated the performance of the partial coherence (PCOH) method, and compared it with the coherence method (COH). The PCOH method allows the elimination of the influence of SaO2 on HbD/rSO2/TOI in a linear way. We started from long-term recordings measured in the first days of life simultaneously in 30 infants from three medical centres. We then compared the COH and PCOH results with patient clinical characteristics and outcomes, and concluded that PCOH might be a better method for assessing impaired autoregulation.

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4 citations in Web of Science®
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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:March 2010
Deposited On:20 May 2010 15:14
Last Modified:05 Apr 2016 14:08
Publisher:Springer US
Series Name:Advances in Experimental Medicine and Biology
Number:662
ISSN:0065-2598
ISBN:978-1-4419-1239-8 (P) 978-1-4419-1241-1 (E)
Free access at:Related URL. An embargo period may apply.
Publisher DOI:https://doi.org/10.1007/978-1-4419-1241-1_31
Official URL:http://www.springerlink.com/content/n762m57j2lx83u6t/
Related URLs:ftp://ftp.esat.kuleuven.be/sista/ddesmet/reports/0808-1-ISOTT.pdf
http://opac.nebis.ch/F/?local_base=NEBIS&con_lng=GER&func=find-b&find_code=SYS&request=005985781
PubMed ID:20204795

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