Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-3419

Soliz, J; Soulage, C; Borter, E; van Patot, M T; Gassmann, M (2008). Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 295(2):649-658.

[img] PDF - Registered users only
View at publisher


Proteins harboring a Per-Arnt-Sim (PAS) domain are versatile and allow archaea, bacteria and plants to sense oxygen partial pressure as well as light intensity and redox potential. A PAS domain associated with a histidine kinase domain is found in FixL, the oxygen sensor molecule of Rhizobium species. Considering the PAS fold PASKIN is the mammalian homolog of FixL, but its function is far from being understood. Using whole body plethysmography we evaluated the ventilatory response to acute and chronic hypoxia of homozygous deficient male and female PASKIN mice (Paskin-/-). While only slight ventilatory differences were found in males, female Paskin-/- mice increased ventilatory response to acute hypoxia. Unexpectedly, females had an impaired ability to reach ventilatory acclimatization in response to chronic hypoxia. Central control of ventilation occurs in the brainstem respiratory centers and is modulated by catecholamines via tyrosine hydroxylase (TH) activity. We observed that TH activity was altered in male and female Paskin-/- mice. Peripheral chemoreceptor effects on ventilation were evaluated by exposing animals to hyperoxia (Dejours test) and domperidone, a peripheral ventilatory stimulant drug directly affecting the carotid sinus nerve discharge. Male and female Paskin-/- had normal peripheral chemosensory (carotid bodies) responses. In summary, our observations suggest that PASKIN is involved in the central control of hypoxic ventilation, modulating ventilation in a gender-dependent manner.


13 citations in Web of Science®
14 citations in Scopus®
Google Scholar™



5 downloads since deposited on 02 Sep 2008
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:August 2008
Deposited On:02 Sep 2008 08:46
Last Modified:05 Apr 2016 12:26
Publisher:American Physiological Society
Publisher DOI:10.1152/ajpregu.00876.2007
PubMed ID:18509100

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page