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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-34230

Lange, C E; Tobler, K; Brandes, K; Breithardt, K; Ordeix, L; Von Bomhard, W; Favrot, C (2010). Canine inverted papillomas associated with DNA of four different papillomaviruses. Veterinary Dermatology, 21(3):287-291.

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Abstract

Abstract Inverted papillomas are uncommon papillomavirus (PV)-induced canine skin lesions. They consist of cup- to dome-shaped dermal nodules with a central pore filled with keratin. Histologically they are characterized by endophytic projections of the epidermis extending into dermis. Cytopathic effects of PVs infection include the presence of clumped keratohyalin granules, koilocytes and intranuclear inclusion bodies. Different DNA hybridization studies carried out with a canine oral papillomavirus (COPV) probe suggested that a different PV than COPV might cause these lesions. Canine papillomavirus 2 (CPV2) was discovered a few years ago in inverted papillomas of immunosuppressed beagles. Two other cases, presenting with distinct clinical and histological features have also been described. This study was carried out on four dogs with clinical and histological signs of inverted papillomas. Molecular biological analyses confirmed that PV DNA was present in all four lesions but demonstrated that the sequences in each case were different. One corresponded to COPV, the second to CPV2, and the third and fourth to unknown PVs. These findings suggest that inverted papillomas are not caused by one single PV type. Similar observations have also been made in human medicine.

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7 citations in Web of Science®
8 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
DDC:570 Life sciences; biology
Date:June 2010
Deposited On:09 Jul 2010 07:06
Last Modified:30 Oct 2014 15:50
Publisher:Wiley-Blackwell
ISSN:0959-4493
Publisher DOI:10.1111/j.1365-3164.2009.00817.x
PubMed ID:20042038

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