Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-34321
Jiricny, J; Nyström-Lahti, M (2000). Mismatch repair defects in cancer. Current Opinion in Genetics & Development, 10(2):157-161.
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Post-replicative mismatch repair in humans utilises the hMSH2, hMSH6, hMSH3, hMLH1 and hPMS2 genes and possibly the newly identified hMLH3 gene. Recently, a link has been established between hMSH6 mutations and 'atypical' hereditary non-polyposis colon cancer (HNPCC) with an increased incidence of endometrial cancers. To satisfy the need for a diagnostic test capable of differentiating between pathogenic mutations and polymorphisms, several functional assays that fulfil these criteria have been described. These should allow for better diagnosis of HNPCC.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Molecular Cancer Research
07 Faculty of Science > Institute of Molecular Cancer Research
|DDC:||570 Life sciences; biology|
|Deposited On:||09 Jul 2010 08:27|
|Last Modified:||28 Nov 2013 02:58|
|Citations:||Web of Science®. Times Cited: 176|
Scopus®. Citation Count: 189
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