Boss, A; Kolb, A; Hofmann, M; Bisdas, S; Nägele, T; Ernemann, U; Stegger, L; Rossi, C; Schlemmer, H P; Pfannenberg, C; Reimold, M; Claussen, C D; Pichler, B J; Klose, U (2010). Diffusion tensor imaging in a human PET/MR hybrid system. Investigative Radiology, 45(5):270-274.
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PURPOSE: The aim of this study was to test and demonstrate the feasibility of diffusion tensor imaging (DTI) with a hybrid positron emission tomography (PET)/magnetic resonance imaging system for simultaneous PET and magnetic resonance (MR) data acquisition. MATERIALS AND METHODS: All measurements were performed with a prototype hybrid PET/MR scanner dedicated for brain and head imaging. The PET scanner, which is inserted into a conventional 3.0-Tesla high field MR imager equipped with a transmit/receive birdcage head coil, consists of 192 block detectors with a matrix of 12 x 12 lutetium oxyorthosilicate scintillation crystals combined with MR-compatible 3 x 3 avalanche photodiode arrays. In 7 volunteers and 4 patients with brain tumors, DTI was performed during simultaneous PET data readout applying a diffusion weighted echo planar sequence (12 noncollinear directions, echo time (TE)/repetition time (TR) 98 ms/5300 ms, b-value 800 s/mm). Image quality and accuracy of DTI were assessed in comparison with DTI images acquired after removal of the PET insert. RESULTS: The diffusion images showed good image quality in all volunteers regardless of simultaneous PET data readout or after removal of the PET scanner; however, significantly (P < 0.01) stronger rim artifacts were found in fractional anisotropy images computed from DTI images recorded during simultaneous PET acquisition, demonstrating higher eddy-current effects. In region of interest analysis, no notable differences were found in the computation of the direction of the principal eigenvector (P > 0.05) and fractional anisotropy values (P > 0.05). In the assessment of pathologies, in all 4 patients PET and DTI provided important clinical information in addition to conventional magnetic resonance imaging. CONCLUSION: Diffusion tensor imaging may be combined with simultaneous PET data acquisition, offering additional important morphologic and functional information for treatment planning in patients with brain tumors.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology|
|DDC:||610 Medicine & health|
|Deposited On:||11 Jun 2010 09:23|
|Last Modified:||27 Nov 2013 19:10|
|Publisher:||Lippincott Wiliams & Wilkins|
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