Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-34525
von Mering, C; Hugenholtz, P; Raes, J; Tringe, S G; Doerks, T; Jensen, L J; Ward, N; Bork, P (2007). Quantitative phylogenetic assessment of microbial communities in diverse environments. Science, 315(5815):1126-1130.
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The taxonomic composition of environmental communities is an important indicator of their ecology and function. We used a set of protein-coding marker genes, extracted from large-scale environmental shotgun sequencing data, to provide a more direct, quantitative, and accurate picture of community composition than that provided by traditional ribosomal RNA-based approaches depending on the polymerase chain reaction. Mapping marker genes from four diverse environmental data sets onto a reference species phylogeny shows that certain communities evolve faster than others. The method also enables determination of preferred habitats for entire microbial clades and provides evidence that such habitat preferences are often remarkably stable over time.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
08 University Research Priority Programs > Systems Biology / Functional Genomics
|DDC:||570 Life sciences; biology|
|Deposited On:||09 Jul 2010 15:52|
|Last Modified:||27 Nov 2013 18:22|
|Publisher:||American Association for the Advancement of Science (AAAS)|
|Citations:||Web of Science®. Times Cited: 147|
Scopus®. Citation Count: 156
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