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Animal models for retinal degeneration


Samardzija, M; Neuhauss, S C F; Joly, S; Kurz-Levin, M; Grimm, C (2010). Animal models for retinal degeneration. In: Pang, I-H; Clark, A F. Animal Models of Retinal Disease. New York: The Humana Press Inc, 51-79.

Abstract

Retinal degeneration is often used to describe a category of human eye diseases, which are characterized by photoreceptor loss leading to severe visual impairment and blindness. An important, yet heterogeneous group of such diseases is called Retinitis Pigmentosa (RP). To understand the molecular mechanisms of disease induction and progression and to develop therapeutical strategies for the preservation of vision in RP patients, appropriate animal models are used in many research laboratories worldwide. The largest category of models consists of mutant (spontaneous and genetically engineered) mice. However, in recent years, zebrafish has been established as a highly valuable tool for the study of various biological problems, including retinal degeneration. In this review, we summarize the currently available mouse and zebrafish models to study retinal degeneration and give a short overview about recent developments in the field.

Retinal degeneration is often used to describe a category of human eye diseases, which are characterized by photoreceptor loss leading to severe visual impairment and blindness. An important, yet heterogeneous group of such diseases is called Retinitis Pigmentosa (RP). To understand the molecular mechanisms of disease induction and progression and to develop therapeutical strategies for the preservation of vision in RP patients, appropriate animal models are used in many research laboratories worldwide. The largest category of models consists of mutant (spontaneous and genetically engineered) mice. However, in recent years, zebrafish has been established as a highly valuable tool for the study of various biological problems, including retinal degeneration. In this review, we summarize the currently available mouse and zebrafish models to study retinal degeneration and give a short overview about recent developments in the field.

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8 citations in Web of Science®
5 citations in Scopus®
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Additional indexing

Item Type:Book Section, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Ophthalmology Clinic
07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2010
Deposited On:05 Jul 2010 15:03
Last Modified:05 Apr 2016 14:10
Publisher:The Humana Press Inc
Series Name:Neuromethods
Number:46
ISSN:0893-2336 (P) 1940-6045 (E)
ISBN:978-1-60761-540-8 (P) 978-1-60761-541-5 (E)
Publisher DOI:10.1007/978-1-60761-541-5_4
Official URL:http://dx.doi.org/10.1007/978-1-60761-541-5
Permanent URL: http://doi.org/10.5167/uzh-34541

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