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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-34634

Obrist, D; Weber, B; Buck, A; Jenny, P (2010). Red blood cell distribution in simplified capillary networks. Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences, 368(1921):2897-9218.

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Abstract

A detailed model of red blood cell (RBC) transport in a capillary network is an indispensable element of a comprehensive model for the supply of the human organism with oxygen and nutrients. In this paper, we introduce a two-phase model for the perfusion of a capillary network. This model accounts for the special role of RBCs, which have a strong influence on network dynamics. Analytical results and numerical simulations with a discrete model and a generic network topology indicate that there exists a local self-regulation mechanism for the flow rates and a global de-mixing process that leads to an inhomogeneous haematocrit distribution. Based on the results from the discrete model, we formulate an efficient algorithm suitable for computing the pressure and flow field as well as a continuous haematocrit distribution in large capillary networks at steady state.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:28 June 2010
Deposited On:06 Jul 2010 12:59
Last Modified:11 Feb 2014 22:26
Publisher:The Royal Society
ISSN:1364-503X
Publisher DOI:10.1098/rsta.2010.0045
PubMed ID:20478913
Citations:Web of Science®. Times Cited: 14
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Scopus®. Citation Count: 12

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