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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-34834

Walter, Anne; Barysch, Marjam J; Behnke, Silvia; Dziunycz, Piotr; Schmid, Bruno; Ritter, Erika; Gnjatic, Sacha; Kristiansen, Glen; Moch, Holger; Knuth, Alexander; Dummer, Reinhard; van den Broek, Maries (2010). Cancer testis antigens and immunosurveillance in human cutaneous squamous cell and basal cell carcinomas. Clinical Cancer Research, 16(14):3562-3570.

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PURPOSE: Non melanoma skin cancer (NMSC) is the most common cancer and comprises basal cell (BCC) and squamous cell carcinoma (SCC). The incidence of SCC increases drastically in immunosuppressed individuals, suggesting a critical role of the immune system in controlling SCC. To find an explanation for the selective immunosurveillance of SCC, we investigated the expression of cancer-testis antigens (CTA), MHC class I and the infiltration by immune cells in BCC and SCC. Experimental design: We determined the expression of 23 different CTA in 63 BCC and 40 SCC biopsies of immunocompetent and in 20 biopsies of immunosuppressed SCC patients by RT-PCR and immunohistochemistry. IgG responses to 36 tumor antigens were measured by Western Blotting and ELISA. MHC-I expression and CD8+ T cell infiltration were analyzed by immunohistochemistry in BCC and SCC of immunocompetent and immunosuppressed patients and in imiquimod-treated BCC patients.RESULTS: We found expression of at least one CTA in 81% of BCC and in 40% of SCC. We did not detect CTA-specific serum IgG. Most SCC, but not BCC, expressed MHC-I and were infiltrated with CD8+ cells. Imiquimod-treated BCC expressed MHC-I and were infiltrated by CD8+ T cells.CONCLUSIONS: We propose that immunosurveillance controls SCC, but not BCC, as the latter lacks MHC-I. This fits with the increased incidence of SCC in immunosuppressed individuals and may explain the relatively low prevalence of CT-antigen expression in SCC as a result of CD8+ T cell driven immunoediting.


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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology
04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology
Dewey Decimal Classification:610 Medicine & health
Date:15 July 2010
Deposited On:14 Jul 2010 19:31
Last Modified:05 Apr 2016 14:11
Publisher:American Association for Cancer Research
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1158/1078-0432.CCR-09-3136
PubMed ID:20519358

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