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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-34845

Janach, M; Kühne, A; Seifert, Burkhardt; French, L E; Ballmer-Weber, B; Hofbauer, G F L (2010). Changing delayed-type sensitizations to the baseline series allergens over a decade at the Zurich University Hospital. Contact Dermatitis, 63(1):42-78.

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BACKGROUND: Patch testing detects delayed-type sensitizations and may show changes in prevalence over time. OBJECTIVES: To compare sensitization prevalence to our baseline series allergens during the years 2000-2004 to results from 1990 to 1994. METHODS: We analysed baseline patch test series allergens from 2000 through 2004. RESULTS: 4094 individuals were patch tested to the baseline series (mean age 45.4 years, males 41.7%). The highest sensitization rates were found for nickel sulfate (19.3%), fragrance mix (10.4%) and Myroxylon pereirae (7.8%). Compared to 1990-1994, methylchloroisothiazolinone (and) methylisothiazoline (MCI/MI) and neomycin sulfate sensitization decreased and lanolin alcohol, thiuram mix and ammoniated mercury sensitization increased. CONCLUSIONS: Current sensitization rates are similar to those across Europe. Reduced sensitizations to MCI/MI and neomycin sulfate and increased sensitizations to thiuram mix and ammoniated mercury chloride may well be because of changes in exposure. The current group comprises a higher proportion affected by leg dermatitis and may thus explain the higher sensitization to lanolin alcohol. Comparing patch results over time shows important changes in sensitization prevalence.


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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Date:June 2010
Deposited On:15 Jul 2010 08:49
Last Modified:05 Apr 2016 14:11
Publisher DOI:10.1111/j.1600-0536.2010.01727.x
PubMed ID:20597933

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