Quick Search:

uzh logo
Browse by:

The deadline for the annual report 2015 is January 31st, 2016

Zurich Open Repository and Archive

Maintenance: Tuesday, 16.2.2015, 06:00-08:00

Maintenance work on various system components of ZORA. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-35096

Stieger, B (2010). Role of the bile salt export pump, BSEP, in acquired forms of cholestasis. Drug Metabolism Reviews, 42(3):437-445.

Accepted Version
View at publisher


Generation of bile is a key function of the liver. Its impairment leads to accumulation of cytotoxic bile salts in hepatocytes and, consequently, to liver disease. The bile salt export pump, BSEP, is critically involved in the secretion of bile salts into bile. Its function can be disturbed or abolished by inherited mutations. This will lead to progressive intrahepatic cholestais and severe liver disease. In addition to mutations, BSEP can be inhibited by acquired factors, such as xenobiotics or drugs, aberrant bile salt metabolites, or pregnancy. This inhibition will lead to acquired cholestasis. Some drugs are now known to be competitive inhibitors of Bsep. In addition, a polymorphism in the gene coding for BSEP has been identified as a potential susceptibility factor for acquired cholestasis.


27 citations in Web of Science®
36 citations in Scopus®
Google Scholar™



134 downloads since deposited on 19 Jul 2010
19 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:610 Medicine & health
Deposited On:19 Jul 2010 08:45
Last Modified:28 Nov 2013 02:10
Publisher:Informa Healthcare
Publisher DOI:10.3109/03602530903492004
PubMed ID:20028269

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page