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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-35107

Lam, J M; Globas, C; Cerny, J; Hertler, B; Uludag, K; Forrester, L W; Macko, R F; Hanley, D F; Becker, C; Luft, A R (2010). Predictors of response to treadmill exercise in stroke survivors. Neurorehabilitation and Neural Repair, 24(6):567-574.

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Abstract

BACKGROUND: Aerobic treadmill exercise (T-EX) therapy has been shown to benefit walking and cardiorespiratory fitness in stroke survivors with chronic gait impairment even long after their stroke. The response, however, varies between individuals. OBJECTIVE: The purpose of this post hoc analysis of 2 randomized controlled T-EX trials was to identify predictors for therapy response. METHODS: In all, 52 participants received T-EX for 3 (Germany) or 6 (United States) months. Improvements in overground walking velocity (10 m/6-min walk) and fitness (peak VO(2)) were indicators of therapy response. Lesion location and volume were measured on T1-weighted magnetic resonance scans. RESULTS: T-EX significantly improved gait and fitness, with gains in 10-m walk tests ranging between +113% and -25% and peak VO(2) between -12% and 88%. Baseline walking impairments or fitness deficits were not predictive of therapy response; 10-m walk velocity improved more in those with subcortical rather than cortical lesions and in patients with smaller lesions. Improvements in 6-minute walk velocity were greater in those with more recent strokes and left-sided lesions. No variable other than training intensity, which was different between trials, predicted fitness gains. CONCLUSIONS: Despite proving overall effectiveness, the response to T-EX varies markedly between individuals. Whereas intensity of aerobic training seems to be an important predictor of gains in cardiovascular fitness, lesion size and location as well as interval between stroke onset and therapy delivery likely affect therapy response. These findings may be used to guide the timing of training and identify subgroups of patients for whom training modalities could be optimized.

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21 citations in Web of Science®
19 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
DDC:610 Medicine & health
Language:English
Date:2010
Deposited On:19 Jul 2010 13:16
Last Modified:27 Nov 2013 20:40
Publisher:Sage Publications
ISSN:1545-9683
Publisher DOI:10.1177/1545968310364059
PubMed ID:20453154

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