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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-35120

Schmitz-Hübsch, T; Coudert, M; Giunti, P; Globas, C; Baliko, L; Fancellu, R; Mariotti, C; Filla, A; Rakowicz, M; Charles, P; Ribai, P; Szymanski, S; Infante, J; van de Warrenburg, B P; Dürr, A; Timmann, D; Boesch, S; Rola, R; Depondt, C; Schöls, L; Zdzienicka, E; Kang, J S; Ratzka, S; Kremer, B; Schulz, J B; Klopstock, T; Melegh, B; du Montcel, S T; Klockgether, T (2010). Self-rated health status in spinocerebellar ataxia--results from a European multicenter study. Movement Disorders, 25(5):587-595.

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Abstract

Patient-based measures of subjective health status are increasingly used as outcome measures in interventional trials. We aimed to determine the variability and predictors of subjective health ratings in a possible target group for future interventions: the spinocerebellar ataxias (SCAs). A consecutive sample of 526 patients with otherwise unexplained progressive ataxia and genetic diagnoses of SCA1 (117), SCA2 (163), SCA3 (139), and SCA6 (107) were enrolled at 18 European referral centers. Subjective health status was assessed with a generic measure of health related quality of life, the EQ-5D (Euroqol) questionnaire. In addition, we performed a neurological examination and a screening questionnaire for affective disorders (patient health questionnaire). Patient-reported health status was compromised in patients of all genotypes (EQ-5D visual analogue scale (EQ-VAS) mean 61.45 +/- 20.8). Specifically, problems were reported in the dimensions of mobility (86.9% of patients), usual activities (68%), pain/discomfort (49.4%), depression/anxiety (46.4%), and self care (38.2%). Multivariate analysis revealed three independent predictors of subjective health status: ataxia severity, extent of noncerebellar involvement, and the presence of depressive syndrome. This model explained 30.5% of EQ-VAS variance in the whole sample and might be extrapolated to other SCA genotypes.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
DDC:610 Medicine & health
Language:English
Date:2010
Deposited On:17 Aug 2010 15:02
Last Modified:03 Jan 2014 06:39
Publisher:Wiley-Blackwell
ISSN:0885-3185
Publisher DOI:10.1002/mds.22740
PubMed ID:20175183
Citations:Web of Science®. Times Cited: 10
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