Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-35347
Niederkofler, V; Baeriswyl, T; Ott, R; Stoeckli, E T (2010). Nectin-like molecules/SynCAMs are required for post-crossing commissural axon guidance. Development, 137(3):427-435.
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The Necl/SynCAM subgroup of immunoglobulin superfamily cell adhesion molecules has been implicated in late stages of neural circuit formation. They were shown to be sufficient for synaptogenesis by their trans-synaptic interactions. Additionally, they are involved in myelination, both in the central and the peripheral nervous system, by mediating adhesion between glia cells and axons. Here, we show that Necls/SynCAMs are also required for early stages of neural circuit formation. We demonstrate a role for Necls/SynCAMs in post-crossing commissural axon guidance in the developing spinal cord in vivo. Necl3/SynCAM2, the family member that has not been characterized functionally so far, plays a crucial role in this process. It is expressed by floorplate cells and interacts with Necls/SynCAMs expressed by commissural axons to mediate a turning response in post-crossing commissural axons.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|DDC:||570 Life sciences; biology|
|Uncontrolled Keywords:||Axon guidance, In ovo RNAi, Nectin-like, Nectin, Midline crossing, Chicken embryo, Spinal cord development|
|Date:||7 January 2010|
|Deposited On:||09 Aug 2010 07:27|
|Last Modified:||27 Nov 2013 23:58|
|Publisher:||Company of Biologists|
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