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Nectin-like molecules/SynCAMs are required for post-crossing commissural axon guidance


Niederkofler, V; Baeriswyl, T; Ott, R; Stoeckli, E T (2010). Nectin-like molecules/SynCAMs are required for post-crossing commissural axon guidance. Development, 137(3):427-435.

Abstract

The Necl/SynCAM subgroup of immunoglobulin superfamily cell adhesion molecules has been implicated in late stages of neural circuit formation. They were shown to be sufficient for synaptogenesis by their trans-synaptic interactions. Additionally, they are involved in myelination, both in the central and the peripheral nervous system, by mediating adhesion between glia cells and axons. Here, we show that Necls/SynCAMs are also required for early stages of neural circuit formation. We demonstrate a role for Necls/SynCAMs in post-crossing commissural axon guidance in the developing spinal cord in vivo. Necl3/SynCAM2, the family member that has not been characterized functionally so far, plays a crucial role in this process. It is expressed by floorplate cells and interacts with Necls/SynCAMs expressed by commissural axons to mediate a turning response in post-crossing commissural axons.

The Necl/SynCAM subgroup of immunoglobulin superfamily cell adhesion molecules has been implicated in late stages of neural circuit formation. They were shown to be sufficient for synaptogenesis by their trans-synaptic interactions. Additionally, they are involved in myelination, both in the central and the peripheral nervous system, by mediating adhesion between glia cells and axons. Here, we show that Necls/SynCAMs are also required for early stages of neural circuit formation. We demonstrate a role for Necls/SynCAMs in post-crossing commissural axon guidance in the developing spinal cord in vivo. Necl3/SynCAM2, the family member that has not been characterized functionally so far, plays a crucial role in this process. It is expressed by floorplate cells and interacts with Necls/SynCAMs expressed by commissural axons to mediate a turning response in post-crossing commissural axons.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:Axon guidance, In ovo RNAi, Nectin-like, Nectin, Midline crossing, Chicken embryo, Spinal cord development
Language:English
Date:7 January 2010
Deposited On:09 Aug 2010 07:27
Last Modified:05 Apr 2016 14:13
Publisher:Company of Biologists
ISSN:0950-1991
Publisher DOI:10.1242/dev.042515
PubMed ID:20056680
Permanent URL: http://doi.org/10.5167/uzh-35347

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