Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-35347

Niederkofler, V; Baeriswyl, T; Ott, R; Stoeckli, E T (2010). Nectin-like molecules/SynCAMs are required for post-crossing commissural axon guidance. Development, 137(3):427-435.

View at publisher


The Necl/SynCAM subgroup of immunoglobulin superfamily cell adhesion molecules has been implicated in late stages of neural circuit formation. They were shown to be sufficient for synaptogenesis by their trans-synaptic interactions. Additionally, they are involved in myelination, both in the central and the peripheral nervous system, by mediating adhesion between glia cells and axons. Here, we show that Necls/SynCAMs are also required for early stages of neural circuit formation. We demonstrate a role for Necls/SynCAMs in post-crossing commissural axon guidance in the developing spinal cord in vivo. Necl3/SynCAM2, the family member that has not been characterized functionally so far, plays a crucial role in this process. It is expressed by floorplate cells and interacts with Necls/SynCAMs expressed by commissural axons to mediate a turning response in post-crossing commissural axons.


19 citations in Web of Science®
23 citations in Scopus®
Google Scholar™



41 downloads since deposited on 09 Aug 2010
17 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:Axon guidance, In ovo RNAi, Nectin-like, Nectin, Midline crossing, Chicken embryo, Spinal cord development
Date:7 January 2010
Deposited On:09 Aug 2010 07:27
Last Modified:05 Apr 2016 14:13
Publisher:Company of Biologists
Publisher DOI:10.1242/dev.042515
PubMed ID:20056680

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page