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Comment on recent modeling studies of astrocyte-neuron metabolic interactions


Jolivet, R; Allaman, I; Pellerin, L; Magistretti, P J; Weber, B (2010). Comment on recent modeling studies of astrocyte-neuron metabolic interactions. Journal of Cerebral Blood Flow and Metabolism, (30):1982-1986.

Abstract

Recent years have seen a surge in mathematical modeling of the various aspects of neuron-astrocyte interactions, and the field of brain energy metabolism is no exception in that regard. Despite the advent of biophysical models in the field, the long-lasting debate on the role of lactate in brain energy metabolism is still unresolved. Quite the contrary, it has been ported to the world of differential equations. Here, we summarize the present state of this discussion from the modeler's point of view and bring some crucial points to the attention of the non-mathematically proficient reader.Journal of Cerebral Blood Flow & Metabolism advance online publication, 11 August 2010; doi:10.1038/jcbfm.2010.132.

Recent years have seen a surge in mathematical modeling of the various aspects of neuron-astrocyte interactions, and the field of brain energy metabolism is no exception in that regard. Despite the advent of biophysical models in the field, the long-lasting debate on the role of lactate in brain energy metabolism is still unresolved. Quite the contrary, it has been ported to the world of differential equations. Here, we summarize the present state of this discussion from the modeler's point of view and bring some crucial points to the attention of the non-mathematically proficient reader.Journal of Cerebral Blood Flow & Metabolism advance online publication, 11 August 2010; doi:10.1038/jcbfm.2010.132.

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Additional indexing

Item Type:Journal Article, not refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2010
Deposited On:16 Aug 2010 13:04
Last Modified:05 Apr 2016 14:13
Publisher:Nature Publishing Group
ISSN:0271-678X
Publisher DOI:https://doi.org/10.1038/jcbfm.2010.132
PubMed ID:20700131
Permanent URL: https://doi.org/10.5167/uzh-35438

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